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Spindle assembly factor. Additionally we are shipping TPX2 Proteins (5) and TPX2 Kits (3) and many more products for this protein.
Showing 10 out of 157 products:
Human Polyclonal TPX2 Primary Antibody for FACS, ICC - ABIN152993
Heidebrecht, Buck, Steinmann, Sprenger, Wacker, Parwaresch: p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. in Blood 1997
Show all 21 references for ABIN152993
Human Polyclonal TPX2 Primary Antibody for EIA, IHC (p) - ABIN357426
Heidebrecht, Adam-Klages, Szczepanowski, Pollmann, Buck, Endl, Kruse, Rudolph, Parwaresch: repp86: A human protein associated in the progression of mitosis. in Molecular cancer research : MCR 2003
Show all 5 references for ABIN357426
Human Polyclonal TPX2 Primary Antibody for WB - ABIN658474
Bibby, Tang, Faisal, Drosopoulos, Lubbe, Houlston, Bayliss, Linardopoulos: A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. in The Journal of biological chemistry 2009
Show all 3 references for ABIN658474
Cow (Bovine) Polyclonal TPX2 Primary Antibody for WB - ABIN2782527
Szczepanowski, Adam-Klages, Kruse, Pollmann, Klapper, Parwaresch, Heidebrecht: Regulation of repp86 stability by human Siah2. in Biochemical and biophysical research communications 2007
Human Monoclonal TPX2 Primary Antibody for ICC, IF - ABIN261644
Itoh, Sugino, Ikeda, Mizuguchi, Kanno, Amin, Iemura, Yasui, Hirota, Tanaka: Nucleoporin Nup188 is required for chromosome alignment in mitosis. in Cancer science 2013
Human Polyclonal TPX2 Primary Antibody for IHC, ELISA - ABIN1534193
Manda, Kohno, Matsuno, Takenoshita, Kuwano, Yokota: Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. in Genomics 1999
MiR (show MLXIP Antibodies)-491 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by downregulating the expression of TPX2.
expression of both TPX2 and PD-L1 (show CD274 Antibodies) are associated with persistence/recurrence of cervical intraepithelial neoplasia after cervical conization
the levels and distribution of TPX2 are likely to be determinants of when and where kinesin-5 acts in neurons.
TPX2 was a target gene of miR (show MLXIP Antibodies)-491.
Propose TPX2 and AURKA (show AURKA Antibodies) as novel co-regulators on the MYC (show MYC Antibodies) pathway in colorectal neoplasms.
Aurora A (show AURKA Antibodies)-dependent TPX2 phosphorylation controls mitotic spindle length through regulating microtubule flux.
These results indicated that TPX2 has an impact on tumor angiogenesis in pancreatic cancer.
Data show that cytoskeleton associated protein 5 (chTOG (show CKAP5 Antibodies)) only weakly promotes importin (show KPNA4 Antibodies)-regulated microtubule nucleation, but acts synergistically with TPX2 protein.
RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 (show XPO7 Antibodies) and TPX2 have roles in serous epithelial ovarian cancer
a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers
Study demonstrates that the Golgi resident protein GM130 (show GOLGA2 Antibodies) activates the spindle assembly factor TPX2 (show DAZL Antibodies) to nucleate microtubules around the Golgi and further captures them to couple mitotic membranes to the spindle.
The findings indicated that Tpx2 (show DAZL Antibodies) is essential for maintaining genomic stability through its role in spindle regulation.
Tpx2 (show DAZL Antibodies) redistributes from the nucleus to the apical process, and promotes nuclear migration during G2-phase by altering microtubule organization.
observations explain the poleward accumulation of Eg5 (show KIF11 Antibodies) in early mitosis and its redistribution in anaphase. Inhibition of dynein blocked Eg5 (show KIF11 Antibodies) movement on microtubules, whereas depletion of the Eg5 (show KIF11 Antibodies)-binding protein TPX2 resulted in end-directed Eg5 (show KIF11 Antibodies) movement.
Data suggest that poleward transport of TPX2, which requires dynein and Eg5, down-regulates its microtubule nucleating activity near kinetochores and links microtubules to dynein for incorporation into the spindle.
Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity).
TPX2, microtubule-associated, homolog (Xenopus laevis)
, targeting protein for Xklp2-like
, TPX2, microtubule-associated protein homolog
, TPX2, microtubule-associated, homolog
, differentially expressed in cancerous and non-cancerous lung cells 2
, differentially expressed in lung cells
, hepatocellular carcinoma-associated antigen 519
, preferentially expressed in colorectal cancer
, protein fls353
, restricted expression proliferation associated protein 100
, restricted expression proliferation-associated protein 100
, targeting protein for Xklp2