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TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) Proteins (TPX2)

Spindle assembly factor. Additionally we are shipping TPX2 Antibodies (121) and TPX2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPX2 22974 Q9ULW0
Rat TPX2 TPX2 311546  
TPX2 72119 A2APB8
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Top TPX2 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human His tag   50 μg Log in to see 10 to 12 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

TPX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

More Proteins for TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) Interaction Partners

Human TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) interaction partners

  1. MiR (show MLXIP Proteins)-491 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by downregulating the expression of TPX2.

  2. expression of both TPX2 and PD-L1 (show CD274 Proteins) are associated with persistence/recurrence of cervical intraepithelial neoplasia after cervical conization

  3. the levels and distribution of TPX2 are likely to be determinants of when and where kinesin-5 acts in neurons.

  4. TPX2 was a target gene of miR (show MLXIP Proteins)-491.

  5. Propose TPX2 and AURKA (show AURKA Proteins) as novel co-regulators on the MYC (show MYC Proteins) pathway in colorectal neoplasms.

  6. Aurora A (show AURKA Proteins)-dependent TPX2 phosphorylation controls mitotic spindle length through regulating microtubule flux.

  7. These results indicated that TPX2 has an impact on tumor angiogenesis in pancreatic cancer.

  8. Data show that cytoskeleton associated protein 5 (chTOG) only weakly promotes importin-regulated microtubule nucleation, but acts synergistically with TPX2 protein.

  9. RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 have roles in serous epithelial ovarian cancer

  10. a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers

Mouse (Murine) TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) interaction partners

  1. Study demonstrates that the Golgi resident protein GM130 (show GOLGA2 Proteins) activates the spindle assembly factor TPX2 (show DAZL Proteins) to nucleate microtubules around the Golgi and further captures them to couple mitotic membranes to the spindle.

  2. The findings indicated that Tpx2 (show DAZL Proteins) is essential for maintaining genomic stability through its role in spindle regulation.

  3. Tpx2 (show DAZL Proteins) redistributes from the nucleus to the apical process, and promotes nuclear migration during G2-phase by altering microtubule organization.

Pig (Porcine) TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) interaction partners

  1. observations explain the poleward accumulation of Eg5 (show KIF11 Proteins) in early mitosis and its redistribution in anaphase. Inhibition of dynein blocked Eg5 (show KIF11 Proteins) movement on microtubules, whereas depletion of the Eg5 (show KIF11 Proteins)-binding protein TPX2 resulted in end-directed Eg5 (show KIF11 Proteins) movement.

  2. Data suggest that poleward transport of TPX2, which requires dynein and Eg5, down-regulates its microtubule nucleating activity near kinetochores and links microtubules to dynein for incorporation into the spindle.

TPX2 Protein Profile

Protein Summary

Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity).

Gene names and symbols associated with TPX2

  • TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2)
  • TPX2, microtubule-associated (TPX2)
  • TPX2, microtubule-associated (Tpx2)
  • TPX2, microtubule-associated protein homolog (Xenopus laevis) (Tpx2)
  • 2610005B21Rik protein
  • C20orf1 protein
  • C20orf2 protein
  • DIL-2 protein
  • DIL2 protein
  • FLS353 protein
  • GD:C20orf1 protein
  • HCA519 protein
  • HCTP4 protein
  • p100 protein
  • REPP86 protein
  • TPX2 protein

Protein level used designations for TPX2

TPX2, microtubule-associated, homolog (Xenopus laevis) , targeting protein for Xklp2-like , TPX2, microtubule-associated protein homolog , TPX2, microtubule-associated, homolog , differentially expressed in cancerous and non-cancerous lung cells 2 , differentially expressed in lung cells , hepatocellular carcinoma-associated antigen 519 , preferentially expressed in colorectal cancer , protein fls353 , restricted expression proliferation associated protein 100 , restricted expression proliferation-associated protein 100 , targeting protein for Xklp2

100053648 Equus caballus
712961 Macaca mulatta
100010953 Monodelphis domestica
100392169 Callithrix jacchus
100469500 Ailuropoda melanoleuca
100585181 Nomascus leucogenys
22974 Homo sapiens
311546 Rattus norvegicus
72119 Mus musculus
477186 Canis lupus familiaris
507226 Bos taurus
100524467 Sus scrofa
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