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TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) ELISA Kits

Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Additionally we are shipping TIFA Antibodies (34) and TIFA Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human TIFA TIFA 92610 Q96CG3
Anti-Mouse TIFA TIFA 211550 Q793I8
Anti-Rat TIFA TIFA 310877 Q5XIB9
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More ELISA Kits for TIFA Interaction Partners

Human TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) interaction partners

  1. This study reports the crystal structures of TIFA (show IL22 ELISA Kits) (residues 1-150, with the unstructured C-terminal tail truncated) and its complex with the N-terminal phosphothreonine9 peptide (residues 1-15).

  2. an innate immune signaling axis, mediated by phosphorylation-dependent oligomerization of the TRAF-interacting protein with forkhead-associated domain (TIFA) that is triggered by heptose-1,7-bisphosphate.

  3. identify a novel threonine phosphorylation site on TIFA (show IL22 ELISA Kits) and show that this phosphorylated threonine binds with the FHA (show CRY2 ELISA Kits) domain of TIFA (show IL22 ELISA Kits), leading to TIFA (show IL22 ELISA Kits) oligomerization and TIFA (show IL22 ELISA Kits)-mediated NF-kappaB (show NFKB1 ELISA Kits) activation

  4. TIFA (show IL22 ELISA Kits) induces the oligomerization and polyubiquitination of TRAF6 (show TRAF6 ELISA Kits), which leads to the activation of TAK1 (show MAP3K7 ELISA Kits) and IKK (show CHUK ELISA Kits) through a proteasome-independent mechanism

Mouse (Murine) TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) interaction partners

  1. The increase in TIFA level appears to be a feed-forward mechanism involved in TLR4 (show TLR4 ELISA Kits)/MyD88 (show MYD88 ELISA Kits)-dependent signaling, leading to NF-kappaB (show NFKB1 ELISA Kits) activation and HMGB1 (show HMGB1 ELISA Kits) release

  2. TIFA is likely to mediate IRAK-1 (show IRAK1 ELISA Kits)/TRAF6 (show TRAF6 ELISA Kits) interaction upon IL-1 (show IL1A ELISA Kits) stimulation

  3. We propose that ZCCHC11 (show ZCCHC11 ELISA Kits) is a unique TLR signal regulator, which interacts with TIFA after LPS (show TLR4 ELISA Kits) treatment and suppresses the TRAF6 (show TRAF6 ELISA Kits)-dependent activation of NF-kappaB (show NFKB1 ELISA Kits).

TIFA Antigen Profile

Antigen Summary

Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity).

Gene names and symbols associated with TIFA

  • TRAF-interacting protein with forkhead-associated domain (TIFA) antibody
  • TRAF-interacting protein with forkhead-associated domain (tifa) antibody
  • TRAF-interacting protein with forkhead-associated domain (Tifa) antibody
  • Ab2-389 antibody
  • T2bp antibody
  • T6BP antibody
  • TIFA antibody
  • TIFAA antibody
  • xtifa antibody

Protein level used designations for TIFA

TRAF-interacting protein with forkhead-associated domain , TRAF-interacting protein with a forkhead-associated domain , TRAF-interacting protein with FHA domain-containing protein A , TRAF6-binding protein , TRAF2 binding protein , TRAF2-binding protein , TRAF6 binding protein , putative MAPK-activating protein PM14 , putative NF-kappa-B-activating protein 20 , Traf2 binding protein

GENE ID SPECIES
422692 Gallus gallus
471278 Pan troglodytes
487905 Canis lupus familiaris
100216213 Xenopus (Silurana) tropicalis
92610 Homo sapiens
211550 Mus musculus
310877 Rattus norvegicus
783855 Bos taurus
734184 Xenopus laevis
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