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TRAF-Interacting Protein with Forkhead-Associated Domain Proteins (TIFA)

Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Additionally we are shipping TIFA Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TIFA 92610 Q96CG3
TIFA 211550 Q793I8
Rat TIFA TIFA 310877 Q5XIB9
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Top TIFA Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,414.50
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,418.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,440.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details

TIFA Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced TIFA Proteins

  1. Human TIFA Protein expressed in Escherichia coli (E. coli) - ABIN668024 : Ea, Sun, Inoue, Chen: TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 2 references for ABIN668024

More Proteins for TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) Interaction Partners

Human TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) interaction partners

  1. This study reports the crystal structures of TIFA (show IL22 Proteins) (residues 1-150, with the unstructured C-terminal tail truncated) and its complex with the N-terminal phosphothreonine9 peptide (residues 1-15).

  2. an innate immune signaling axis, mediated by phosphorylation-dependent oligomerization of the TRAF-interacting protein with forkhead-associated domain (TIFA) that is triggered by heptose-1,7-bisphosphate.

  3. identify a novel threonine phosphorylation site on TIFA (show IL22 Proteins) and show that this phosphorylated threonine binds with the FHA (show CRY2 Proteins) domain of TIFA (show IL22 Proteins), leading to TIFA (show IL22 Proteins) oligomerization and TIFA (show IL22 Proteins)-mediated NF-kappaB (show NFKB1 Proteins) activation

  4. TIFA (show IL22 Proteins) induces the oligomerization and polyubiquitination of TRAF6 (show TRAF6 Proteins), which leads to the activation of TAK1 (show MAP3K7 Proteins) and IKK (show CHUK Proteins) through a proteasome-independent mechanism

Mouse (Murine) TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) interaction partners

  1. The increase in TIFA level appears to be a feed-forward mechanism involved in TLR4 (show TLR4 Proteins)/MyD88 (show MYD88 Proteins)-dependent signaling, leading to NF-kappaB (show NFKB1 Proteins) activation and HMGB1 (show HMGB1 Proteins) release

  2. TIFA is likely to mediate IRAK-1 (show IRAK1 Proteins)/TRAF6 (show TRAF6 Proteins) interaction upon IL-1 (show IL1A Proteins) stimulation

  3. We propose that ZCCHC11 (show ZCCHC11 Proteins) is a unique TLR signal regulator, which interacts with TIFA after LPS (show TLR4 Proteins) treatment and suppresses the TRAF6 (show TRAF6 Proteins)-dependent activation of NF-kappaB (show NFKB1 Proteins).

TIFA Protein Profile

Protein Summary

Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity).

Gene names and symbols associated with TIFA

  • TRAF-interacting protein with forkhead-associated domain (TIFA)
  • TRAF-interacting protein with forkhead-associated domain (tifa)
  • TRAF-interacting protein with forkhead-associated domain (Tifa)
  • Ab2-389 protein
  • T2bp protein
  • T6BP protein
  • TIFA protein
  • TIFAA protein
  • xtifa protein

Protein level used designations for TIFA

TRAF-interacting protein with forkhead-associated domain , TRAF-interacting protein with a forkhead-associated domain , TRAF-interacting protein with FHA domain-containing protein A , TRAF6-binding protein , TRAF2 binding protein , TRAF2-binding protein , TRAF6 binding protein , putative MAPK-activating protein PM14 , putative NF-kappa-B-activating protein 20 , Traf2 binding protein

GENE ID SPECIES
422692 Gallus gallus
471278 Pan troglodytes
487905 Canis lupus familiaris
100216213 Xenopus (Silurana) tropicalis
92610 Homo sapiens
211550 Mus musculus
310877 Rattus norvegicus
783855 Bos taurus
734184 Xenopus laevis
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