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Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008].. Additionally we are shipping TNIK Proteins (5) and TNIK Kits (2) and many more products for this protein.
Showing 10 out of 159 products:
Human Polyclonal TNIK Primary Antibody for EIA, IHC (p) - ABIN358244
Taira, Umikawa, Takei, Myagmar, Shinzato, Machida, Uezato, Nonaka, Kariya: The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton. in The Journal of biological chemistry 2004
Show all 3 references for ABIN358244
Human Polyclonal TNIK Primary Antibody for IHC (p), WB - ABIN392499
Wang, Charych, Pulito, Lee, Graziane, Crozier, Revilla-Sanchez, Kelly, Dunlop, Murdoch, Taylor, Xie, Pausch, Hayashi-Takagi, Ishizuka, Seshadri, Bates, Kariya, Sawa, Weinberg, Moss, Houslay, Yan et al.: The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. ... in Molecular psychiatry 2011
Show all 2 references for ABIN392499
Human Monoclonal TNIK Primary Antibody for ELISA, WB - ABIN564994
Mahmoudi, Li, Ng, Taouatas, Vries, Mohammed, Heck, Clevers: The kinase TNIK is an essential activator of Wnt target genes. in The EMBO journal 2009
Human Monoclonal TNIK Primary Antibody for IF, WB - ABIN968788
Fu, Shen, Huang, Lasaga, Payan, Luo: TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. in The Journal of biological chemistry 1999
Human Polyclonal TNIK Primary Antibody for EIA, IHC (p) - ABIN360387
Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001
High expression of TNIK in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients.
Endogenous substrates of TNIK were identified in neurons, along with consensus sequences for TNIK.
nuclear p-TNIK expression was studied in hepatocellular carcinoma, and p-TNIK nuclear expression was associated with poor prognosis and is a candidate prognostic marker for hepatocellular carcinoma
Dynamic change of TNIK offers a way to protect cells from outside stimulus.
TNIK mediates proliferation and survival of EBV-transformed B-cells.
TNIK is essential for the activation of both the canonical Wnt (show WNT2 Antibodies) pathway and the JNK (show MAPK8 Antibodies) pathway, and serves as a pro-survival factor.
TNIK is a specific effector of Rap2 to regulate actin cytoskeleton
This study demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain.
TNiK is required for dentate gyrus neurogenesis & for pattern separation in a 2-choice spatial discrimination task & for glutamate (show GRIN1 Antibodies)-dependent object-location paired associate learning.
TNIK maintains levels of glutamate receptors and other key postsynaptic density (PSD) proteins at the synapse, with loss of TNIK protein or inhibition of TNIK activity causing rapid degradation of PSD constituents.
siRNA depletion of TNIK followed by expression array analysis showed that TNIK is an essential, specific activator of Wnt (show WNT2 Antibodies) transcriptional programme.
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999
TRAF2 and NCK interacting kinase
, TRAF2 and NCK-interacting protein kinase-like
, TRAF2 and NCK-interacting protein kinase
, traf2 and NCK-interacting protein kinase
, Traf2 and NCK interacting kinase