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TSPYL2 encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. Additionally we are shipping TSPY-Like 2 Proteins (3) and many more products for this protein.
Showing 10 out of 71 products:
Human Polyclonal TSPYL2 Primary Antibody for WB - ABIN1881953
Chai, Sarcevic, Mawson, Toh: SET-related cell division autoantigen-1 (CDA1) arrests cell growth. in The Journal of biological chemistry 2001
Show all 5 references for ABIN1881953
homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 (show LRP2 Antibodies) and TSPYL2 genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability
Authors demonstrate that human coilin-interacting nuclear ATPase protein (hCINAP) is a novel negative regulator in NF-kappaB (show NFKB1 Antibodies) signaling by deactivating IkappaB kinase (show CHUK Antibodies) (IKK (show CHUK Antibodies)) complex.
TSPYL2 is an essential component of the REST/NRSF (show REST Antibodies) transcriptional complex for TGFbeta (show TGFB1 Antibodies) signaling activation
The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC (show FAM126A Antibodies) and related liver cancers in male-biased manners.
More importantly, RPS14 (show RPS14 Antibodies) was specifically modified with NEDD8 (show NEDD8 Antibodies) and hCINAP inhibited RPS14 (show RPS14 Antibodies) NEDDylation by recruiting NEDD8-specific protease 1 (show SENP8 Antibodies)
TSPX is principally expressed in Sertoli cells in the human testis.
knockdown of CINAP expression results in marked reduction of histone transcription, lower levels of U small nuclear RNAs (U1, U2, U4, and U5), and a loss of cell viability
Overexpression of cell division autoantigen-1 (CDA1) slowed parasite growth and induced expression of bradyzoite-specific proteins. Results showed that changes in host cell transcription can influence the molecular environment for bradyzoite development.
CDA1 induces p53 (show TP53 Antibodies)- and MEK (show MAP2K1 Antibodies)/ERK1/2 (show MAPK1/3 Antibodies) MAPK (show MAPK1 Antibodies)-dependent expression of p21 (show CDKN1A Antibodies) by acting through the p53 (show TP53 Antibodies) responsive element in the p21 (show CDKN1A Antibodies) promoter and this contributes to its antiproliferative activity
a role for DENTT as a suppressor of the tumorigenic phenotype.
Following infection with T. gondii, myotubes but not myoblasts or fibroblasts further upregulate the negative cell cycle regulator (show CDKN2A Antibodies) Tspyl2.
We conclude that TSPYL2 contributes to cognitive variability through regulating the expression of Grin2a (show GRIN2A Antibodies) and Grin2b (show GRIN2B Antibodies).
CDA1 deletion reduces but does not block renal TGF-beta (show TGFB1 Antibodies) signaling.
TSPYL2 serves a biological role in maintaining the G1 checkpoint under stress condition.
DENTT may play a role in development of the endocrine tissues, nervous system, lung, oocytes, and thecal cells, and testis [DENTT]
DENTT may play multiple roles in modulating transcriptional responses suggesting new roles for the TTSN superfamily during embryogenesis and differentiation.
Mice treated with hypertonic saline expressed higher CINAP protein levels in the PVN, supporting a role of CINAP in neural response in vivo.
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth.
, testis-specific Y-encoded protein 2
, testis-specific Y-encoded protein Q1
, CASK-interacting nucleosome assembly protein
, CTCL tumor antigen se20-4
, CTCL-associated antigen se20-4
, TSPY-like protein 2
, cell division autoantigen 1
, cutaneous T-cell lymphoma-associated antigen se20-4
, cutaneous T-cell lymphoma-associated tumor antigen se20-4
, differentially expressed nucleolar TGF-beta1 target
, differentially-expressed nucleolar TGF-beta1 target protein
, nuclear protein of 79 kDa
, testis-specific Y-encoded-like protein 2
, testis-specific protein Y encoded-like 2
, CASK interacting nucleosome assembly protein
, cell division autoantigen 1 nucleolar protein
, nucleolar TGF-beta1 target protein