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anti-TXK tyrosine Kinase (TXK) Antibodies

Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Additionally we are shipping TXK tyrosine Kinase Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TXK 7294 P42681
TXK 22165 P42682
TXK 305311  
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Top anti-TXK tyrosine Kinase Antibodies at antibodies-online.com

Showing 10 out of 55 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated EIA, WB AP31071PU-N TXK antibody staining of of Human Tonsil lysate at 2 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-TXK Pab (ABIN392114) in Jurkat cell lysate. TXK (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$396.00
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged TXK is 0.3 ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated IHC (p), ELISA Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details

TXK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine) ,
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Rat (Rattus)


Top referenced anti-TXK tyrosine Kinase Antibodies

  1. Human Polyclonal TXK Primary Antibody for EIA, IHC (p) - ABIN359999 : Takeba, Nagafuchi, Takeno, Kashiwakura, Suzuki: Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. in Journal of immunology (Baltimore, Md. : 1950) 2002 (PubMed)
    Show all 3 references for ABIN359999

  2. Human Polyclonal TXK Primary Antibody for EIA, WB - ABIN783924 : Suzuki, Nara, Suzuki: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. in Clinical medicine & research 2006 (PubMed)

More Antibodies against TXK tyrosine Kinase Interaction Partners

Human TXK tyrosine Kinase (TXK) interaction partners

  1. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK (show ITK Antibodies) and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.

  2. fuctions as a Th1 (show TH1L Antibodies) cell-specific transcription factor and regulates IFN-gamma (show IFNG Antibodies) gene transcription

  3. Th1 (show TH1L Antibodies) cells expressing Txk and Th1 (show TH1L Antibodies)-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease.

  4. Itk (show ITK Antibodies) and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 (show TH1L Antibodies) responses.

Mouse (Murine) TXK tyrosine Kinase (TXK) interaction partners

  1. Taken together, these data indicate that ITK (show ITK Antibodies) plus RLK inhibition may have therapeutic potential in Th1 (show HAND1 Antibodies)-mediated inflammatory diseases.

  2. TXK plays an overlapping role with ITK (show ITK Antibodies) in iNKT cell development and function. ITK (show ITK Antibodies) also has a unique function in the survival of iNKT cells, likely via a p53 (show TP53 Antibodies)-dependent pathway.

  3. The protein data combined with the association constants for binding of each proline-rich peptide to the corresponding SH3 domain (show ITSN1 Antibodies) provide an explanation for the opposing modes of self-association within the otherwise closely related Rlk and Itk (show ITK Antibodies) proteins

  4. Tec kinases play key roles in regulating TCR-mediated polarization of integrins and signaling molecules to the site of TCR stimulation as well as the up-regulation of integrin adhesion.

  5. A role for Rlk kinase is demonstrated in CD8 (show CD8A Antibodies)+ T cell signaling and function both in vitro and in vivo.

  6. indicate a critical role for Itk (show ITK Antibodies) and Rlk in conventional CD8 (show CD8A Antibodies)(+) T cell development in the thymus

  7. Tec kinases differentially regulate development of conventional versus nonconventional lymphocytes

  8. Tec (show NR4A3 Antibodies) kinases Rlk and Itk (show ITK Antibodies) together provide important signals for terminal maturation, efficient cytokine production, and peripheral survival of natural killer T (NKT (show CTSL1 Antibodies)) cells.

TXK tyrosine Kinase (TXK) Antigen Profile

Protein Summary

Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

Gene names and symbols associated with TXK

  • TXK tyrosine kinase (TXK) antibody
  • insulin receptor (INSR) antibody
  • Janus kinase 1 (JAK1) antibody
  • spleen tyrosine kinase (SYK) antibody
  • TXK tyrosine kinase (Txk) antibody
  • A130089B16Rik antibody
  • Btkl antibody
  • CTK-1 antibody
  • PSCTK5 antibody
  • PTK4 antibody
  • Rlk antibody
  • TKL antibody

Protein level used designations for TXK

tyrosine-protein kinase TXK , TXK tyrosine kinase , tyrosine-protein kinase TXK-like , insulin receptor tyrosine kinase , tyrosine kinase , Janus kinase 1 (a protein tyrosine kinase) , protein tyrosine kinase , protein-tyrosine kinase , tyrosine-protein kinase SYK , PTK4 protein tyrosine kinase 4 , protein-tyrosine kinase 4 , resting lymphocyte kinase , PTK-RL-18

GENE ID SPECIES
444993 Sus scrofa
461344 Pan troglodytes
482139 Canis lupus familiaris
504782 Bos taurus
705104 Macaca mulatta
770387 Gallus gallus
100019276 Monodelphis domestica
100054343 Equus caballus
100341671 Oryctolagus cuniculus
100397226 Callithrix jacchus
100455862 Pongo abelii
100464564 Ailuropoda melanoleuca
100544958 Meleagris gallopavo
100598060 Nomascus leucogenys
420133 Gallus gallus
442952 Canis lupus familiaris
100125540 Sus scrofa
7294 Homo sapiens
22165 Mus musculus
305311 Rattus norvegicus
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