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Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Proteins (TNKS2)

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Additionally we are shipping Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Antibodies (57) and Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNKS2 80351 Q9H2K2
TNKS2 74493 Q3UES3
Rat TNKS2 TNKS2 309512  
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Top Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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TNKS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) Interaction Partners

Human Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) interaction partners

  1. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (show PARP1 Proteins)/2 and tankyrase 1 (show TNKS Proteins)/2 inhibitor which has the advantage of targeting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling addicted tumors.

  2. Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC (show FAM126A Proteins) with aberrant WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.

  3. TNKS2 is recruited to DNA lesions by MDC1 and promotes homologous recombination in response to DNA double strand breaks.

  4. The variability of genes encoding for TERF1 (show TERF1 Proteins) and TNKS2 is important for keeping the integrity of the telomere structure and show a significant association with longevity.

  5. Studies show a significant interaction of IWR1 with acidic and polar residues (Asp (show ASIP Proteins) and Tyr (show TYR Proteins)) in the hydrophobic region at the induced pocket of TNKS1 (show TNKS Proteins)/TNKS2. These two residues are the key for the mechanism of inhibition of TNKS (show TNKS Proteins) proteins.

  6. Data indicate a basis for development of flavones as tankyrase inhibitors and suggest the development of other structurally related inhibitors.

  7. Data suggest that miR (show MLXIP Proteins)-20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2.

  8. Study reports crystal structures of a representative ankyrin repeat clusters of TNKS2 bound to targeting peptides from six substrates.

  9. RNF146 (show RNF146 Proteins) RING-type ubiquitin E3 ligase as a positive regulator of Wnt (show WNT2 Proteins) signaling that operates with tankyrase to maintain low steady-state levels of Axin (show AXIN1 Proteins) proteins

  10. TNKS2 bound to Epstein-Barr virus origin of plasmid replication in coimmunoprecipitation experiments with transfected cell lysates.

Mouse (Murine) Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) interaction partners

  1. TNKS2 is required in insulin (show INS Proteins)-stimulated glucose disposal.

  2. Study shows that TNKS2, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation in osteoclasts; cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction.

  3. Data show that Tnks1 (show TNKS Proteins) and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt (show WNT2 Proteins) ligands.

  4. inactivation of tankyrase 2 does not result in the alteration in telomere length when monitored through multiple generations of breeding, tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism.

  5. Tnks2 has a role in normal growth and development but is not essential for telomere length maintenance or telomere capping in mice.

  6. tankyrase 2is essential but redundant for mouse embryonic development

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) Protein Profile

Protein Summary

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (By similarity).$.

Gene names and symbols associated with TNKS2

  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (TNKS2)
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (tnks2)
  • tankyrase-2-like (LOC100855568)
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (Tnks2)
  • 5430432P15Rik protein
  • AA517131 protein
  • AI662480 protein
  • ARTD6 protein
  • PARP-5b protein
  • PARP-5c protein
  • PARP5B protein
  • PARP5C protein
  • pART6 protein
  • Tank2 protein
  • tankyrase-2 protein
  • TNKL protein
  • TNKS-2 protein
  • TNKS2 protein

Protein level used designations for TNKS2

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 , tankyrase-2 , tankyrase-2-like , ADP-ribosyltransferase diphtheria toxin-like 6 , TNKS-2 , TRF1-interacting ankyrin-related ADP-ribose polymerase 2 , poly [ADP-ribose] polymerase 5B , tankyrase 2 , tankyrase II , tankyrase-like protein , tankyrase-related protein

GENE ID SPECIES
477767 Canis lupus familiaris
533901 Bos taurus
698050 Macaca mulatta
100061968 Equus caballus
100391147 Callithrix jacchus
100539557 Meleagris gallopavo
100567928 Anolis carolinensis
100591011 Nomascus leucogenys
100855568 Canis lupus familiaris
80351 Homo sapiens
74493 Mus musculus
309512 Rattus norvegicus
100154520 Sus scrofa
374253 Gallus gallus
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