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TOM1 was identified as a target of the v-myb oncogene. Additionally we are shipping TOM1 Antibodies (34) and TOM1 Kits (1) and many more products for this protein.
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Tom1 modulates binding of Tollip (show TOLLIP Proteins) to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism.
phosphatidylinositol 5-monophosphate (PI5P) enrichment in signaling endosomes prevents endosomal maturation through the recruitment of TOM1, and point to a new function of PI5P in regulating discrete maturation steps in the endosomal system.
It was shown that that myosin VI (show MYO6 Proteins), in concert with Tom1, plays a crucial role in autophagy. Tom1 was identified as a myosin VI (show MYO6 Proteins) binding partner on endosomes.
TOM1 is a microRNA-126 target that may have an important role in regulating innate immune responses in the cystic fibrosis (show S100A8 Proteins) lung.
a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin
marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin (show ZFYVE16 Proteins) or its carboxyl-terminal fragment
Tollip (show TOLLIP Proteins) and Tom1 form a complex and regulate endosomal trafficking of ubiquitinated proteins
The results suggest that TOM1 is an important molecule for membrane recruitment of clathrin, and that endofin (show ZFYVE16 Proteins) is able to exploit this recruitment at the endosome.
A 3-marker haplotype of SNPs within TOM1 was associated with psychotic bipolar affective disorder linkage
These results indicate that, in conjunction with Tollip, Tom1 family proteins play an important role in recruiting clathrin onto endosomes and suggest that they modulate endosomal functions.
This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
target of Myb protein 1
, target of myb 1