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TASP1 encodes an endopeptidase that cleaves specific substrates following aspartate residues. Additionally we are shipping Taspase, Threonine Aspartase, 1 Antibodies (44) and many more products for this protein.
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Taspase1 deficiency disrupts the expression of cyclins and proliferation of HER2 (show ERBB2 Proteins)+ breast cancer cells.
TFIIA (show GTF2A1 Proteins) is the principal TASP1 substrate that orchestrates craniofacial morphogenesis.
Taspase1 cleaves a ubiquitously expressed GTF (TFIIA (show GTF2A1 Proteins)) to enable tissue-specific (testis) transcription, meeting the demand for sophisticated regulation of distinct subsets of genes in higher organisms.
TASP1, EPS15R, and PRPF3 (show PRPF3 Proteins) expression were significantly induced in HCCs (show HCCS Proteins) of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha (show HNF4A Proteins)
Studies indicate that threonine Aspartase1 (Taspase1) is overexpressed in numerous liquid and solid malignancies and was characterized as a 'non-oncogene (show RAB1A Proteins) addiction' protease.
simultaneous expression of the leukemogenic AF4-MLL (show MLL Proteins) and dnTASP1 causes the disappearance of the leukemogenic oncoprotein, because the uncleaved AF4-MLL (show MLL Proteins) protein (328 kDa) is subject to proteasomal degradation.
Our results provide first evidence that Taspase1 processing affects TFIIA (show GTF2A1 Proteins) regulation of TFIID (show TBP Proteins) and suggest that Taspase1 processing of TFIIA (show GTF2A1 Proteins) is required to establish INR (show INSR Proteins)-selective core promoter activity in the presence of NC2 (show GTF2H5 Proteins).
Taspase1 appears to exploit the nuclear export activity of importin-alpha/nucleophosmin (show NPM1 Proteins) to gain transient access to the cytoplasm required to also cleave its cytoplasmic substrates.
Cell-based analysis of structure-function activity of threonine aspartase 1.
purification and cloning of threonine aspartase 1 responsible for cleaving MLL (show MLL Proteins); RNAi-mediated knockdown of Taspase1 results in the appearance of unprocessed MLL (show MLL Proteins) and the loss of proper HOX (show MSH2 Proteins) gene expression
Transfected taspase 1 enhances cleavage of TFIIA (show GTF2A1 Proteins), and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA (show GTF2A1 Proteins) in vivo.
This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
, threonine aspartase 1
, taspase 1