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TAS2R38 encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Additionally we are shipping Taste Receptor, Type 2, Member 38 Antibodies (36) and Taste Receptor, Type 2, Member 38 Kits (9) and many more products for this protein.
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TAS2R38 genotype and 6-n-propylthiouracil sensitivity status revealed high percentage of non-tasters. Food preferences and BMI did not significantly correlate TAS2R38 genotype.
T2R38 is stimulated by acyl-homoserine lactones, gram-negative quorum-sensing molecules, and subsequently activates nitric oxide-dependent innate immune responses. The formation of mature cilia is necessary for T2R38 expression and function, and polymorphisms that underlie T2R38 functionality appear to be involved in susceptibility to upper respiratory infection and recalcitrant CRS (show CARS Proteins).
Genetic Variation in the TAS2R38
Immunohistochemistry of human ileum tissues was performed in this study, which showed that TAS2R38 was co-localized with glucagon-like peptide 1 (GLP-1 (show GCG Proteins)) in enteroendocrine L-cells.
Study did not find an association between TAS2R38 genotype and chronic rhinosinusitis (CRS (show CARS Proteins)), thus questioning its real contribution to CRS (show CARS Proteins) susceptibility.
The expression of TAS2R38 in placental tissues points to further new functions and hitherto unknown endogenous ligands of TAS2Rs far beyond bitter tasting.
Our investigation indicates that T2R38 genotype correlates both with SNOT-22 scores and rhinologic-specific quality of life in DeltaF508 homozygous cystic fibrosis (show S100A8 Proteins) patients
Variability in perceived bitterness of capsaicin and ethanol were significantly associated with TAS2R38
This study suggest that: 1) alexithymia, in addition to the TAS2R38 polymorphism, may play a role in responsiveness to the aversive and bitter taste of PROP; and 2) alexithymia.
phagocytes are activated via a rather specialized receptor that was not previously described on myeloid cells, the bitter taste receptor T2R38.
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant).
taste receptor, type 2, member 38
, taste receptor, type 2, member 7-like
, taste receptor type 2 member 38
, taste receptor type 2 member 26
, PTC bitter taste receptor
, taste receptor type 2 member 61
, bitter taste receptor TAS2R38