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TCTN1 encodes a member of the tectonic family of secreted and transmembrane proteins. Additionally we are shipping Tectonic Family Member 1 Proteins (3) and many more products for this protein.
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Human Polyclonal TCTN1 Primary Antibody for EIA, IF - ABIN783637
Reiter, Skarnes: Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. in Genes & development 2006
These findings confirmed the direct association between the TCTN1 gene and prostate cancer growth in vitro.
These data suggest TCTN1 is essential for glioma cell viability, and dysregulation of TCTN1 may play a key role in glioma tumorigenesis.
TCTN1 may serve as a novel prognostic factor and a potential therapeutic target for glioblastoma.
Mutations in Tctn1 is associated with ciliopathies.
Loss of Tctn1 is associated with ciliopathies.
During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (show SHH Antibodies) (Hh) pathway activation. Tectonic plays an additional role in repressing Hh pathway activity.
This gene encodes a member of the tectonic family of secreted and transmembrane proteins. The orthologous gene in mouse is required for formation of most ventral cell types. It functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
tectonic family member 1
, tectonic 1