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Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. Additionally we are shipping Tenascin R (Restrictin, Janusin) Kits (40) and Tenascin R (Restrictin, Janusin) Antibodies (37) and many more products for this protein.
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Two genes, TNR (and TNK2 (show TNK2 Proteins)), were found to have genetic variations linked to familial Parkinson's Disease.
TnC (show TNC Proteins) and TnR play important roles in nervous and immune systems. [Review]
citation presents comparison with human gene.
results show that tenascin-R expression is tightly regulated in a spatiotemporal manner during brain development, especially cortical plate formation; its pattern of expression suggests a role for tenascin-R in corticogenesis
KIAA0510, the 3'-untranslated region of the tenascin-R gene, and tenascin-R are overexpressed in pilocytic astrocytomas
The researchers found evidence that the tenascin R gene is a potential susceptiblity or marker gene for IgA nephropathy.
Tenascin R is expressed and glycosylated in neurons
An extracellular matrix molecule TNR and its associated carbohydrate human natural killer cell glycan (HNK-1 (show B3GAT1 Proteins)) provide conditions beneficial for induction of long-term potentiation in the hippocampus.
Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan (show ACAN Proteins).
Aggrecan (show ACAN Proteins), link protein (show HAPLN1 Proteins) and TN-R were identified to be essential for the neuroprotective properties of the perineuronal net.
These findings indicate the importance of TNR in the regulation of hippocampal neurogenesis and suggest that TNR acts through distinct direct and indirect mechanisms during development and in the adult.
TNR is expressed in a subset of astrocytes and contributes to glutamate (show GRIN1 Proteins) homeostasis by regulating astrocytic GLAST (show SLC1A3 Proteins) expression.
Our results indicate that TNR modulates adult but not developmental neurogenesis in the olfactory bulb
This study provided evidence that the tenascin-R modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs.
Ablation of TNR modifies the extracellular matrix and leads to reorganization of the dentate gyrus with enhanced GABAergic innervation and altered plasticity, promoting working memory and reversal learning.
TN-R appears to play an important role in the regulation of the number and architecture of perisomatic inhibitory synapses onto hippocampal pyramidal cells.
the impact of TN-R deficiency on the living animal
murine tenascin-R gene structure and functional characterisation of the promoter
Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion\; MIM 187380), TNX (TNXB\; MIM 600985), and TNR (Erickson, 1993
, neural recognition molecule J1-160/180
, Tenascin-R (Restrictin janusin J1-160/180)
, Tenascin-R (Restrictin, janusin, J1-160/180)
, tenascin R (restrictin, janusin)