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May play a role in actin remodeling. Additionally we are shipping Tensin 3 Antibodies (18) and and many more products for this protein.
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Results indicate that tensin3 is essential for normal development and functions of the small intestine, lung, and bone [tensin3].
Tns3 protein, including its SH2 domain, is phosphorylated by Src (show SRC ELISA Kits) and contributes to tumorigenesis and metastasis.
A phosphorylation-mediated molecular switch comprising DLC), TNS3, PTEN and PI3K (show PIK3CA ELISA Kits) controls the spatiotemporal activation of Rac1 and RhoA (show RHOA ELISA Kits), thereby initiating directional cell migration induced by growth factors.
The depletion of tensin-3 suppressed breast cancer cell invasiveness.
The phenotypic changes observed in proband cells may arise from TNS3 haploinsufficiency, causing partial loss of full-length Tensin3 protein. Tensin3 plays a rol in cytoskeletal organisation and cell motility.
These results reveal a differential methylation pattern in the TNS3 promoter occurring in human renal cell carcinoma.
Tensin3 may function as a platform for the disassembly of EGF (show EGF ELISA Kits)-related signaling complexes at focal adhesions.
Data show that EGF downregulates tensin-3 expression, and concomitantly upregulates cten, a tensin family member that lacks the actin-binding domain.
TNS3-EXOC6B (show EXOC6B ELISA Kits) and EXOC6B (show EXOC6B ELISA Kits)-TNS3 fusion transcripts are detected in a premature male newborn with a complex multisystemic phenotype associated with a balanced translocation.
Tensin3 mRNA is expressed abundantly in all twelve functional adenomas at almost the same level as in normal thyroid tissue.
May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration (By similarity). May be involved in cell migration and bone development.
, Temporarily Assigned Gene name family member (tag-163)-like
, tensin-like SH2 domain containing 1
, tensin-like SH2 domain-containing protein 1
, tumor endothelial marker 6
, tensin-like SH2 domain-containing 1
, thyroid specific PTB domain protein