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TSSK4 encodes a member of the testis-specific serine/threonine kinase family. Additionally we are shipping TSSK4 Antibodies (33) and many more products for this protein.
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TSSK4 (show TSSK6 Proteins) was able to induce cell apoptosis in vitro depending on its kinase activity, which leads to abnormal testes weight and apoptosis, shedding light on its function in the process of spermatogenesis and/or spermiogenesis
association of some single nucleotide polymorphisms in TSSK4 (show TSSK6 Proteins) with male infertility.
Phosphorylated Tssk4 might participate in testis genes expressions by phosphorylating Crem (show CREM Proteins) at Ser (show SIGLEC1 Proteins)-117.
findings reveal that Tssk4 is required for maintaining the structural integrity of sperm flagellum and male fertility.
HSP90 (show HSP90 Proteins) function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 (show TSSK1B Proteins) and -2. Inhibition of HSP90 (show HSP90 Proteins) resulted in increased TSSK ubiquitination and proteasomal degradation
autophosphorylation at Thr (show TRH Proteins)-197 plays a critical role in maintaining Tssk4 kinase activity, which might be involved in spermiogenesis.
This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.
serine/threonine kinase 22E
, serine/threonine-protein kinase 22E
, testis-specific serine/threonine-protein kinase 4
, testis-specific kinase 4
, testis-specific serine/threonine protein kinase 5 variant alpha
, testis-specific serine/threonine protein kinase 5 variant beta
, testis-specific serine/threonine protein kinase 5 variant delta
, testis-specific serine/threonine protein kinase 5 variant gamma