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TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004. Additionally we are shipping Testis-Specific serine Kinase 1B Proteins (9) and Testis-Specific serine Kinase 1B Antibodies (7) and many more products for this protein.
Report evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
Data show that human testis-specific (show THEG ELISA Kits) serine/threonine (Ser (show SIGLEC1 ELISA Kits)/Thr (show TRH ELISA Kits)) kinase (TSSK) 1 and 2 messages are expressed exclusively in the testis and suggest that this family of kinases might play a role in sperm function.
In mouse testis, PPP1CC2 can form a complex with TSSK1 mediated by the direct interaction of each with the kinase substrate protein TSKS (show TSKS ELISA Kits). Interaction between PPP1CC2 and TSKS (show TSKS ELISA Kits) is mediated through an RVxF docking motif on the TSKS (show TSKS ELISA Kits) surface.
HSP90 (show HSP90 ELISA Kits) function abolished the catalytic activities of TSSK4 (show TSSK4 ELISA Kits) and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 (show HSP90 ELISA Kits) resulted in increased TSSK ubiquitination and proteasomal degradation
Tssk1 and Tssk2 play an important role in the regulation of sperm function.
Results reveal TSSK1- and TSSK2-dependent functions of a transformed chromatoid body in post-meiotic cytodifferentiation of spermatids.
The expression patterns of Tsk1 is documented throughout spermiogenesis showing an initial association of Tsk1 with cells in meiotic metaphase.
Deletion of Tssk2 kinase/substrate pair is predicted to play an indispensable role during spermiogenesis
Results confirm both TSSK 2 and TSKS (show TSKS ELISA Kits) persist in sperm, define a critical role of TSKS (show TSKS ELISA Kits)' N-terminus in enzyme interaction, identify Ser (show SIGLEC1 ELISA Kits) 281 as a TSKS (show TSKS ELISA Kits) phosphorylation site and indicate an indispensable role for TSSK 1 and 2 in spermiogenesis.
TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004
testis-specific serine kinase 1B
, testis-specific serine/threonine-protein kinase 1-like
, testis-specific serine kinase 1
, ANKRD26-like family C, member 2
, testis-specific serine/threonine-protein kinase 1
, serine/threonine kinase 22A (spermiogenesis associated)
, serine/threonine-protein kinase 22A
, testis-specific kinase 1
, testis-specific serine/threonine kinase
, serine/threonine kinase 22D (spermiogenesis associated)
, serine/threonine kinase FKSG81
, spermiogenesis associated 4
, spermiogenesis associated
, testis-specific serine kinase 2