anti-Tet Methylcytosine Dioxygenase 2 (TET2) Antibodies

The protein encoded by TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. Additionally we are shipping TET2 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TET2 54790 Q6N021
TET2 214133 Q4JK59
TET2 310859  
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Top anti-TET2 Antibodies at antibodies-online.com

Showing 10 out of 122 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Goat Un-conjugated EIA, IHC (p)   0.1 mg Log in to see 10 to 12 Days
$375.38
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p)   0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Goat Un-conjugated IHC, ELISA 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated WB TET2 Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TET2 antibody detected the TET2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IP, WB Tes2 mAb (Clone 21F11) tested by Immunoprecipitation. Tet2 detection by Immunoprecipitation. Lane 1: Input (25 µg of HL-60 whole cell lysate). Lane 2: Negative control mAb. Lane 3: Tet2 antibody at 1 µg/ml. 250 µg of HL-60 whole cell lysate per IP. Tes2 mAb (Clone 21F11) tested by Western blot. Tet2 detection by Western blot. Lane 1: HL-60 whole cell lysate (40 µg). Lane 2: Lymphoblastoid Tet2 negative (-/-) whole cell lysate (40 µg). Lane 3: Lymphoblastoid Tet2 positive (+/+) whole cell lysate (40 µg). All probed with Tet2 antibody at a 1 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
$495.83
Details
Human Goat Un-conjugated IHC, ELISA   100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded rat lung using TET2 antibody at dilution of 1:100 (40x lens). 100 μL Log in to see 16 Days
$323.13
Details
Human Rabbit Un-conjugated IP, WB 100 μL Log in to see 16 Days
$460.63
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$446.88
Details

TET2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TET2 Antibodies

  1. Human Monoclonal TET2 Primary Antibody for IP, WB - ABIN2668527 : Wallner, Schröder, Leitão, Berulava, Haak, Beißer, Rahmann, Richter, Manke, Bönisch, Arrigoni, Fröhler, Klironomos, Chen, Rajewsky, Müller, Ebert, Lengauer, Barann, Rosenstiel, Gasparoni, Nordström et al.: Epigenetic dynamics of monocyte-to-macrophage differentiation. ... in Epigenetics & chromatin 2016 (PubMed)
    Show all 2 references for 2668527

  2. Human Polyclonal TET2 Primary Antibody for IHC, ELISA - ABIN571057 : Orr, Haffner, Nelson, Yegnasubramanian, Eberhart: Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. in PLoS ONE 2012 (PubMed)

  3. Human Polyclonal TET2 Primary Antibody for ELISA, IHC - ABIN4358584 : Langemeijer, Kuiper, Berends, Knops, Aslanyan, Massop, Stevens-Linders, van Hoogen, van Kessel, Raymakers, Kamping, Verhoef, Verburgh, Hagemeijer, Vandenberghe, de Witte, van der Reijden, Jansen: Acquired mutations in TET2 are common in myelodysplastic syndromes. in Nature genetics 2009 (PubMed)

More Antibodies against TET2 Interaction Partners

Human Tet Methylcytosine Dioxygenase 2 (TET2) interaction partners

  1. we show that the TET2 expression and 5hmC abundance are significantly altered in the umbilical veins of GDM and preeclampsia.The alteration of TET expression, 5hmC levels and 5hmC-mediated transposon activity was further confirmed using established hypoxia cell culture model, which could be rescued by vitamin C, a known activator of TET proteins

  2. Because the DNA hypomethylation might be a result of TET dioxygenase activity, the study examined expression of TET1 (show TET1 Antibodies)-3 enzymes and the level of their product, 5-hydroxymethylcytosine (5hmC), in a panel of histologically characterized seminomas and non-seminomatous germ cell tumors. The study found highly increased expression of TET1 (show TET1 Antibodies) dioxygenase in most seminomas and strong TET1 (show TET1 Antibodies) staining in seminoma cells.

  3. this study shows that Tet2 expression is increased in intratumoral myeloid cells in melanoma patients

  4. hypermethylation of the MEG3 (show FAM129B Antibodies) promoter in AML (show RUNX1 Antibodies) may result from decreased TET2 activity. These data provide insight into the molecular mechanisms underlying AML (show RUNX1 Antibodies) development and progression

  5. Our findings suggest that TET2 mutations have no prognosis impact on overall survival of patients with myelodysplastic syndromes

  6. ANRIL knockdown blocks the effects of TET2 on gastric cancer cell proliferation and colony formation.

  7. indicate that AID and TET2 share common effects on myeloid and erythroid lineage differentiation, however, their role is nonredundant in regulating HSC (show FUT1 Antibodies) self-renewal and in myeloid transformation.

  8. The prevalence of TET2 mutations in children with acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) compared with adults with AML (show RUNX1 Antibodies) was lower and less complex. Patients with polymorphism I1762V had an increased 10-year survival rate compared with patients without I1762V.

  9. Somatic mutations driving clonal hematopoiesis occur mainly in DNMT3A (show DNMT3A Antibodies) and TET2 and have no significant impact on hematological phenotypes. There is a familial predisposition to acquire TET2 mutation.

  10. findings have identified distinct roles for TET2 and TET3 (show TET3 Antibodies) in human erythropoiesis, and provide new insights into their role in regulating human erythroid differentiation at distinct stages of development.

Mouse (Murine) Tet Methylcytosine Dioxygenase 2 (TET2) interaction partners

  1. in the absence of TET2, mast cell differentiation is under the control of compensatory mechanisms mediated by other TET family members, while proliferation is strictly dependent on TET2 expression.

  2. ablation of Tet2 in myeloid cells suppresses melanoma growth in vivo and shifted the immunosuppressive gene expression program in tumor-associated macrophages to a proinflammatory one

  3. These results support the hypothesis that somatic TET2 mutations in blood cells play a causal role in atherosclerosis.

  4. Loss of TET2 expression is associated with development of malignancy.

  5. confirm the transformation potential of DNMT3A (show DNMT3A Antibodies)(R882H) Tet2(-/-) progenitors and represent the first cooperative model in mice involving Tet2 inactivation driving lymphoid malignancies

  6. indicate that AID and TET2 share common effects on myeloid and erythroid lineage differentiation, however, their role is nonredundant in regulating HSC (show FUT1 Antibodies) self-renewal and in myeloid transformation.

  7. the results showed that low shear stress downregulated endothelial cell autophagy by impaired TET2 expression, which might contribute to the atherogenic process.

  8. Zfp281 (show ZNF281 Antibodies) interacts with Tet1 (show TET1 Antibodies), but not Tet2, and its direct transcriptional target, miR (show MLXIP Antibodies)-302/367, to negatively regulate Tet2 expression to establish and maintain primed pluripotency.

  9. tet2 activity in GnRH neurons has influence over the neuroendocrine control of male reproductive function

  10. this study shows that simultaneous deletion of Tet2 and Tet3 (show TET3 Antibodies) in mouse CD4 (show CD4 Antibodies)+CD8 (show CD8A Antibodies)+ double-positive thymocytes results in dysregulated development and proliferation of invariant natural killer T cells

TET2 Antigen Profile

Protein Summary

The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TET2

  • tet methylcytosine dioxygenase 2 (TET2) antibody
  • tet methylcytosine dioxygenase 2 (Tet2) antibody
  • Ayu17-449 antibody
  • E130014J05Rik antibody
  • KIAA1546 antibody
  • MDS antibody
  • mKIAA1546 antibody
  • RGD1311625 antibody

Protein level used designations for TET2

methylcytosine dioxygenase TET2 , probable methylcytosine dioxygenase TET2 , tet oncogene family member 2 , tet oncogene 2

GENE ID SPECIES
54790 Homo sapiens
478499 Canis lupus familiaris
214133 Mus musculus
310859 Rattus norvegicus
422540 Gallus gallus
100521465 Sus scrofa
538481 Bos taurus
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