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The protein encoded by TSPAN1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping Tetraspanin 1 Antibodies (56) and Tetraspanin 1 Kits (3) and many more products for this protein.
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Human TSPAN1 Protein expressed in Human Cells - ABIN2005409
Nabokina, Senthilkumar, Said: Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability. in American journal of physiology. Gastrointestinal and liver physiology 2011
The present study demonstrated that Tspan1 plays an important role in Pancreatic cancer carcinogenic progression, including migration and invasion.
Restoration of TSPAN1 rescued the effects of miR (show MLXIP Proteins)-573 overexpression. Therefore, our findings suggest that the miR (show MLXIP Proteins)-573/TSPAN1 axis is important in the control of gastric carcinogenesis
our current data demonstrate that miR (show MLXIP Proteins)-638 functions as a tumor suppressor in human colorectal carcinoma by inhibiting TSPAN1
TSPAN1 was proved to induce migration, and so up-regulation of TSPAN1 by miR (show MLXIP Proteins)-200a may explain why over-expressing miR (show MLXIP Proteins)-200a promotes NSCLC cells migration
these data argue against a role for tetraspanin 1 as a genuine mediator of cell surface receptor signalling but rather document a role for tetraspanin 1 in the control of cervical cancer cell motility and invasion.
data suggest that the NET-1 (show SLC6A2 Proteins) gene may play an important role in proliferation, migration and endocytosis in the development and progress of hepatocellular carcinoma
Study provided the gene expression profile of HBV-related HCC (show FAM126A Proteins) and presented differential expression patterns of SATB-1 (show SATB1 Proteins), TM4SF-1 (show TM4SF1 Proteins) and ST-14 (show ST14 Proteins) between cancerous and noncancerous tissues in patients with HBV-related HCC (show FAM126A Proteins).
These studies demonstrate for the first time that Tspan-1 is an interacting partner with human thiamine transporter-1 and that this interaction affects thiamine transporter-1 stability.
TSPAN1 may be another important breast cancer suppressor gene belonging to the tetraspanin superfamily.
RNAi-mediated downregulation of TSPAN1 expression significantly inhibits the proliferation and invasion of colon cancer cells in vitro.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
, tetraspan 1