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The protein encoded by TSPAN8 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping Tetraspanin 8 Antibodies (60) and Tetraspanin 8 Kits (1) and many more products for this protein.
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Human Tetraspanin 8 Protein expressed in Human Cells - ABIN2006626
Betz, Sadler: Variants of a cloned synthetic lactose operator. I. A palindromic dimer lactose operator derived from one stand of the cloned 40-base pair operator. in Gene 1981
overexpression of tm4sf3 promoted development of annular pancreas.
This novel nuclear localization of TM4SF3 depends on androgen-induced nuclear localization of androgen receptor (AR (show AR Proteins)) in both androgen-dependent and androgen-independent prostate cancer cell lines
Our data suggest that TSPAN8-LEL may play an important role in mCRC cell invasion, and that the antibody we have developed could be a useful tool for inhibiting the invasion of TSPAN8-expressing mCRCs.
Based on nasopharyngeal TSPAN8 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants.
CO-029 functions as a regulator of both cell-matrix and cell-cell adhesion. During colon cancer progression, CO-029 promotes cancer cell movement by deregulating cell adhesions.
PMA-induced Tspan8-internalization promotes cell migration, but reduces matrix and cell adhesion.
High TSPAN8 is associated with melanoma invasiveness.
claudin-7 (show CLDN7 Proteins)-associated EpCAM (show EPCAM Proteins) is recruited into (tetraspanin-enriched membrane microdomains) and forms a complex with CO-029 and CD44v6 that facilitates metastasis formation
overexpression of TM4SF3 in esophageal cancer conferred advantage to the invasion and metastasis of this destructive disease
results argue for a role for Tspan8 in body-weight regulation in males, but do not show differences in T2D-associated traits that were anticipated from previous human genome-wide association studies.
Results suggest that alterations in gene expression of Gata6 (show GATA6 Proteins), Tspan8, S100a8 (show S100A8 Proteins), and Lmo2 (show LMO2 Proteins) may act via novel pathways that play functionally important roles in Men1 (show MEN1 Proteins)-associated tumor progression.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.
, transmembrane 4 superfamily member 3
, tumor-associated antigen CO-029