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Involved in biosynthesis of the thiamine precursor thiazole.
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Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
, thiamine biosynthetic enzyme
, thiamine thiazole synthase 1, chloroplastic
, thiazole biosynthetic enzyme 1
, thiazole biosynthetic enzyme 1-1, chloroplastic