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Thimet Oligopeptidase 1 Proteins (THOP1)

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Additionally we are shipping Thimet Oligopeptidase 1 Antibodies (47) and Thimet Oligopeptidase 1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
THOP1 7064 P52888
THOP1 50492 Q8C1A5
THOP1 64517 P24155
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Top Thimet Oligopeptidase 1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Baculovirus infected Insect Cells Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,998.50
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

THOP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Thimet Oligopeptidase 1 (THOP1) Interaction Partners

Human Thimet Oligopeptidase 1 (THOP1) interaction partners

  1. THOP1 may have clinical potentials to be employed as a promising biomarker to identify individuals with better prognosis and a novel antitumor agent for therapy of patients with NSCLC

  2. Low THOP1 expression levels are associated with recurrence of hepatocellular carcinoma.

  3. TCEP. Data indicate that THIMET-oligopeptidase (TOP) oxidation by H2O2 and high valence states of hemeproteins does not lead to enzyme oligomerization.

  4. The semi-quantitative intracellular peptidome analyses of siRNA-transfected HEK293 cells shows that the levels of specific intracellular peptides are either increased or decreased upon EP24.15 inhibition.

  5. human thimet oligopeptidase crystal structure shows substrate recognition, regulation, and localization

  6. EP24.15 associates with AT1 (show AGTR1 Proteins) and B2 receptors both at the plasma membrane and after receptor internalization

  7. Mutations at only two residues (Glu-469 and Arg-498) are required to swap specificity with neurolysin, a result that is confirmed by testing the two-mutant constructs.

  8. increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta (show APP Proteins) load.

  9. Over 100 peptides were identified in human embryonic kidney 293 (HEK293) cells that are derived from intracellular proteins; many but not all of these peptides are substrates or products of EP24.15.

  10. interaction between EP24.15 and calmodulin (show CALM1 Proteins) is regulated within cells and is important for the stimulated secretion of EP24.15 from HEK293 cells.

Mouse (Murine) Thimet Oligopeptidase 1 (THOP1) interaction partners

  1. the cellular peptidases dipeptidyl peptidase 3 (DPP-3 (show DPP3 Proteins)) and thimet oligopeptidase 1 (TOP-1 (show TOP1 Proteins)), both of which are present in nonimmunogenic necrotic cells, eliminated proteasomal degradation products and blocked Ag cross-presentation

  2. Data show that Thimet oligopeptidase (TOP) is coexpressed with estrogen receptor alpha (show ESR1 Proteins), and estradiol regulates TOP expression in a brain region-specific manner in female mice.

  3. EP24.15 association with lipid rafts on the extracellular surface precedes constitutive release of the peptidase into the extracellular milieu for its action on neuropeptides

  4. Melanoma cells secrete thimet oligopeptidase which have an important role in tumor proliferation/angiogenesis in vitro and in vivo.

  5. increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta (show APP Proteins) load.

Cow (Bovine) Thimet Oligopeptidase 1 (THOP1) interaction partners

  1. Cyclic strain putatively regulates both the mRNA expression and enzymatic function of EP24.15 and EP24.16 (show NLN Proteins).

Thimet Oligopeptidase 1 (THOP1) Protein Profile

Protein Summary

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

Gene names and symbols associated with THOP1

  • thimet oligopeptidase 1 (thop1)
  • thimet oligopeptidase 1 (THOP1)
  • thimet oligopeptidase (LOC397806)
  • thimet oligopeptidase (Tc00.1047053506411.10)
  • thimet oligopeptidase (Tc00.1047053511237.10)
  • thimet oligopeptidase (Noca_4613)
  • thimet oligopeptidase (ANI_1_1400064)
  • thimet oligopeptidase (Mboo_2053)
  • thimet oligopeptidase (AOR_1_880174)
  • Thimet oligopeptidase (AnaeK_0425)
  • Thimet oligopeptidase (Mpal_0768)
  • Thimet oligopeptidase (Hoch_5061)
  • Thimet oligopeptidase (mepd)
  • thimet oligopeptidase 1 (Thop1)
  • AI131655 protein
  • AI327041 protein
  • EP24.15 protein
  • LOC397806 protein
  • mepd protein
  • MEPD_HUMAN protein
  • MGC147297 protein
  • MP78 protein
  • thop1 protein
  • TOP protein
  • zgc:92589 protein

Protein level used designations for THOP1

thimet oligopeptidase 1 , thimet oligopeptidase-like , thimet oligopeptidase , Thimet oligopeptidase , endopeptidase 24.15 , PZ-peptidase , endo-oligopeptidase A , metalloendopeptidase , soluble metallo-endopeptidase , endopeptidase EC3.4.24.15

GENE ID SPECIES
449659 Danio rerio
721578 Macaca mulatta
779863 Xenopus (Silurana) tropicalis
100020499 Monodelphis domestica
100385317 Callithrix jacchus
100455971 Pongo abelii
397806 Xenopus laevis
3535960 Trypanosoma cruzi strain CL Brener
3541015 Trypanosoma cruzi strain CL Brener
4596069 Nocardioides sp. JS614
4981318 Aspergillus niger CBS 513.88
5410686 Methanoregula boonei 6A8
5990506 Aspergillus oryzae RIB40
6785830 Anaeromyxobacter sp. K
7270509 Methanosphaerula palustris E1-9c
8547472 Haliangium ochraceum DSM 14365
100194867 Salmo salar
7064 Homo sapiens
50492 Mus musculus
64517 Rattus norvegicus
510889 Bos taurus
397442 Sus scrofa
476748 Canis lupus familiaris
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