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TPMT encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Additionally we are shipping TPMT Proteins (24) and TPMT Kits (10) and many more products for this protein.
Showing 10 out of 112 products:
Human Monoclonal TPMT Primary Antibody for IF, IHC (p) - ABIN563239
Egle, Milek, Mlinaric-Rascan, Fahr, Kristl: A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types. in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008
Show all 2 references for ABIN563239
Human Monoclonal TPMT Primary Antibody for EIA, WB - ABIN781549
Odani, Nakamura, Sato, Fujii: Identification of a rat 30-kDa protein recognized by the antibodies to a recombinant rat cutaneous fatty acid-binding protein as a 14-3-3 protein. in Journal of biochemistry 2001
Human Monoclonal TPMT Primary Antibody for ELISA, WB - ABIN563241
Hayashi, Naoi, Nakagawa, Nishikawa, Fukuda, Imajoh-Ohmi, Kondo, Kubo, Yabuki, Hattori, Hirouchi, Sugiyama: Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4. in The Journal of biological chemistry 2012
These findings support the notion that germline polymorphisms in Tpmt affect not only host tissue toxicity but also antitumor effectiveness.
suggestion that differential mouse TPMT activity is due to variation in mRNA expression
structure-function relationships of TPMT
The TPMT promoter region may serve as a pharmacogenomic biomarker when introducing thiopurine therapy
The most frequently occurring nonfunctional TPMT allele in Croatian population is TPMT*3A. Variant genotypes were statistically significantly more common in Crohn's disease subgroup than in ulcerative colitis subgroup.
Association of TPMT polymorphisms with overall azathioprine-induced adverse drug reactions, bone marrow toxicity and gastric intolerance, but not with hepatotoxicity (meta-analysis).
association of TPMT polymorphisms with overall thiopurine-induced adverse drug reactions
Identification of TPMT variants and subsequent dose reduction reduces hematologic events during thiopurine treatment of inflammatory bowel disease.
TPMT*3c mutant allele was associated with azathioprine side effects (leukopenia, alopecia) in Chinese systemic lupus erythematosus patients.
refinements in risk stratification and treatment have reduced the influence of TPMT genotype on treatment outcome in a contemporary protocol.
We report on the presence of the TPMT*3C and *3A mutant alleles in the Libyan population. Therefore, monitoring the patients to be treated with doses of thiopurine drugs for TPMT variants is worthwhile to avoid the development of severe myelosuppression.
this paper shows that the influence of TPMT and COMT (show COMT Antibodies) on the development of cisplatin-induced hearing loss may be less important than previously suggested.
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
, Thiopurine S-methyltransferase
, S-adenosyl-L-methionine:thiopurine S-methyltransferase
, thiopurine methyltransferase
, NHL repeat containing 1