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Thiopurine S-Methyltransferase Proteins (TPMT)

TPMT encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Additionally we are shipping TPMT Antibodies (104) and TPMT Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPMT 22017 O55060
TPMT 7172 P51580
TPMT 690050  
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Top TPMT Proteins at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Thiopurine S-Methyltransferase (TPMT) (AA 4-244), (partial) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 11 Days
$341.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,610.67
Details
Yeast REACT_African wild dog His tag   1 mg Log in to see 56 to 66 Days
$2,625.33
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,625.33
Details
Yeast Pongo pygmaeus His tag   1 mg Log in to see 56 to 66 Days
$2,625.33
Details

TPMT Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

Top referenced TPMT Proteins

  1. Human TPMT Protein expressed in Escherichia coli (E. coli) - ABIN666697 : Odani, Nakamura, Sato, Fujii: Identification of a rat 30-kDa protein recognized by the antibodies to a recombinant rat cutaneous fatty acid-binding protein as a 14-3-3 protein. in Journal of biochemistry 2001 (PubMed)
    Show all 2 references for ABIN666697

More Proteins for Thiopurine S-Methyltransferase (TPMT) Interaction Partners

Mouse (Murine) Thiopurine S-Methyltransferase (TPMT) interaction partners

  1. With the significant mitigation of TPMT wild type-expressing cells to cisplatin cytotoxicity, findings demonstrate a drug-gene interaction between increased TPMT activity and decreased susceptibility to cisplatin-induced toxicity of inner ear cells.

  2. These findings support the notion that germline polymorphisms in Tpmt affect not only host tissue toxicity but also antitumor effectiveness.

  3. suggestion that differential mouse TPMT activity is due to variation in mRNA expression

Human Thiopurine S-Methyltransferase (TPMT) interaction partners

  1. In a GWAS, TPMT activity in patients behaves as a monogenic trait, further bolstering the utility of TPMT genetic testing in the clinic

  2. Review/Meta-analysis: thiopurine S-methyltransferase testing for averting drug toxicity.

  3. A point mutation in the thiopurine S-methyltransferase gene that led to exon 5 deletion in the transcribed mRNA.

  4. The aims of this research were to investigate the association of TPMT phenotypes with MDR1 genotypes.

  5. The aim of the study was to investigate frequencies of TPMT and ITPA (show ITPA Proteins) polymorphisms in Lithuanian inflammatory bowel disease patients and analyze their association with azathioprine-related adverse events.

  6. With respect to TPMT, the variants TPMT*2 and TPMT*3A were not implicated in genetic susceptibility to childhood acute lymphoblastic leukemia

  7. structure-function relationships of TPMT

  8. The TPMT promoter region may serve as a pharmacogenomic biomarker when introducing thiopurine therapy

  9. The most frequently occurring nonfunctional TPMT allele in Croatian population is TPMT*3A. Variant genotypes were statistically significantly more common in Crohn's disease subgroup than in ulcerative colitis subgroup.

  10. Association of TPMT polymorphisms with overall azathioprine-induced adverse drug reactions, bone marrow toxicity and gastric intolerance, but not with hepatotoxicity (meta-analysis).

TPMT Protein Profile

Protein Summary

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Gene names and symbols associated with TPMT

  • thiopurine S-methyltransferase (tpmt)
  • zgc:101684 (zgc:101684)
  • thiopurine S-methyltransferase (tpm)
  • thiopurine S-methyltransferase (MCA0794)
  • thiopurine S-methyltransferase (Pnap_4948)
  • thiopurine S-methyltransferase (Hhal_1383)
  • thiopurine S-methyltransferase (TK90_1044)
  • thiopurine S-methyltransferase (Slit_1144)
  • thiopurine S-methyltransferase (Tint_0842)
  • Thiopurine S-methyltransferase (Fbal_3334)
  • thiopurine S-methyltransferase (Celly_3188)
  • thiopurine S-methyltransferase (Weevi_1737)
  • Thiopurine S-methyltransferase (Psefu_2696)
  • Thiopurine S-methyltransferase (Metme_3860)
  • thiopurine methyltransferase (Tpmt)
  • thiopurine S-methyltransferase (TPMT)
  • thiopurine S-methyltransferase (Tpmt)
  • AW106912 protein
  • MGC84277 protein
  • NHLRC1 protein

Protein level used designations for TPMT

thiopurine S-methyltransferase , Thiopurine S-methyltransferase , S-adenosyl-L-methionine:thiopurine S-methyltransferase , thiopurine methyltransferase , NHL repeat containing 1

GENE ID SPECIES
447769 Xenopus laevis
573111 Danio rerio
1168449 Shewanella oneidensis MR-1
3104309 Methylococcus capsulatus str. Bath
4685796 Polaromonas naphthalenivorans CJ2
4711327 Halorhodospira halophila SL1
8806802 Thioalkalivibrio sp. K90mix
8891817 Sideroxydans lithotrophicus ES-1
9151573 Thiomonas intermedia K12
9772187 Ferrimonas balearica DSM 9799
10265228 Cellulophaga lytica DSM 7489
10282995 Weeksella virosa DSM 16922
10657285 Pseudomonas fulva 12-X
10673875 Methylomonas methanica MC09
22017 Mus musculus
7172 Homo sapiens
403536 Canis lupus familiaris
511644 Bos taurus
690050 Rattus norvegicus
493759 Felis catus
100034066 Equus caballus
100009411 Oryctolagus cuniculus
471863 Pan troglodytes
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