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This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. Additionally we are shipping Thioredoxin 2 Proteins (22) and Thioredoxin 2 Kits (1) and many more products for this protein.
Showing 10 out of 85 products:
Human Polyclonal TXN2 Primary Antibody for ELISA - ABIN1999771
Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009
Show all 4 references for ABIN1999771
Human Polyclonal TXN2 Primary Antibody for WB - ABIN388139
Damdimopoulos, Miranda-Vizuete, Pelto-Huikko, Gustafsson, Spyrou: Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. in The Journal of biological chemistry 2002
Show all 2 references for ABIN388139
Human Polyclonal TXN2 Primary Antibody for EIA, WB - ABIN356856
Chen, Cai, Murphy, Jones: Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. in The Journal of biological chemistry 2002
Show all 2 references for ABIN356856
Chicken Polyclonal TXN2 Primary Antibody for WB - ABIN2785947
Benhar, Forrester, Hess, Stamler: Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. in Science (New York, N.Y.) 2008
This is the first demonstration of biochemical and physiological consequences caused by loss of Trx-2 in Drosophila.
gene for thioredoxin (DmTrx-2) was cloned and expressed, and the protein characterized
Drosophila thioredoxin can function as an anti-aging agent and as a suppressor of Parkin-associated endothelin receptor-like receptor (show GPR37 Antibodies) - and poly-glutamine (show GFPT2 Antibodies)-induced neurotoxicity
Trx-2 affects lifespan in Drosophila. Mutants have a decreased lifespan.
No evidence that SNPs in TRX2 have effects, but the rs4485648 polymorphism of the TrxR2 (show TXNRD2 Antibodies) gene might exert an independent effect on the development of Diabetic retinopathy.
The results explain how the MLL (show MLL Antibodies) SET domains of MLL1 and MLL4 (show MLL2 Antibodies) are able to add multiple methyl groups to the target histone H3 (show HIST3H3 Antibodies) lysine.
The Aven (show AVEN Antibodies) RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 (show MLL2 Antibodies) mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes.
We propose that MLL3 and MLL4 (show MLL2 Antibodies) are broadly required for controlling MAFA (show KLRG1 Antibodies) and MAFB (show MAFB Antibodies) transactivation during development and postnatally.
Thioredoxin 2 Is a Novel E2-Interacting Protein That Inhibits the Replication of Classical Swine Fever Virus by promoting the nuclear translocation of the p65 (show GORASP1 Antibodies) subunit of NF-kappaB (show NFKB1 Antibodies).
HBV-MLL4 (show MLL2 Antibodies) integration occurred frequently in Chinese HCC (show FAM126A Antibodies) patients, representing a unique molecular segment for HCC (show FAM126A Antibodies) with HBV infection
Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 (show MLL2 Antibodies) and GPS2 (show GPS2 Antibodies) genes, resulting in fusion gene MLL4 (show MLL2 Antibodies)-GPS2 (show GPS2 Antibodies), the expression of which promotes independent growth.
The Grx2 (show GRX2 Antibodies) system could help to keep Trx2/1 reduced during an oxidative stress, thereby contributing to the anti-apoptotic signaling.
CERKL (show CERKL Antibodies) interacts with TRX2 and plays a novel key role in the regulation of the TRX2 antioxidant pathway.
TGF-beta (show TGFB1 Antibodies)-mediated expression of the epithelial-mesenchymal transition marker fibronectin (show FN1 Antibodies) was inhibited not only by chemicals that interfere with reactive oxygen species signaling but also by exogenously expressed mitochondrial thioredoxin.
The ventral signal observed from early stages colocalized with motor neuron markers Isl1 (show ISL1 Antibodies)/2 and FoxP1 (show FOXP1 Antibodies) and the strong ventral signal colocalizing with Isl1 (show ISL1 Antibodies)/2 was observed in all rostrocaudal segments of the spinal cord.
TRX-2 overexpression does not mitigate adverse effects of a high-calorie diet on synaptic plasticity
An essential role was identified for thioredoxin-2 in preserving cardiac function by suppressing mitochondrial reactive oxygen species.
The SirT1 (show SIRT1 Antibodies) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (show SOD2 Antibodies), catalase (show CAT Antibodies), peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2 (show TXNRD2 Antibodies), and uncoupling protein 2 (show UCP2 Antibodies).
This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver and upregulated thioredoxin-2 expression.
Both thioredoxin 2 and glutaredoxin 2 (show GRX2 Antibodies) contribute to the reduction of the mitochondrial 2-Cys (show DNAJC5 Antibodies) peroxiredoxin Prx3 (show PRDX3 Antibodies).
Data show that Nrf2 (show NFE2L2 Antibodies) activity was increased in WT MEFs at the 0 or -46 mV conditions, but was inhibited in Trx2 Tg MEFs under the same conditions.
the rapid E2-mediated activation of the Txn (show TXN Antibodies) pathway is an important step in the response of the mammalian uterus to estrogen.
Trx2 is an endogenous regulator of the mitochondrial permeability transition.
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
, thioredoxin, mitochondrial
, thioredoxin 2
, Thioredoxin 2
, WW domain binding protein 7
, WW domain-binding protein 7
, histone-lysine N-methyltransferase 2B
, histone-lysine N-methyltransferase MLL4
, lysine N-methyltransferase 2B
, lysine N-methyltransferase 2D
, mixed lineage leukemia gene homolog 2
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4
, myeloid/lymphoid or mixed-lineage leukemia 4
, myeloid/lymphoid or mixed-lineage leukemia protein 4
, trithorax homolog 2
, trithorax homologue 2
, mitochondrial thioredoxin
, thioredoxin nuclear gene encoding mitochondrial protein