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regulates thioredoxin to play an important role in the preservation of cellular viability [RGD, Feb 2006].. Additionally we are shipping TXNIP Antibodies (83) and TXNIP Kits (29) and many more products for this protein.
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Glucose exerts strong stimulatory effects on activation histone marks while having inhibitory effects on repression marks in the promoter of the TXNIP gene, and this was associated with a marked increase in expression of the proinflammatory gene in kidney.
No evidence that SNPS in TXNIP has effect, but the rs4485648 polymorphism of the TrxR2 (show TXNRD2 Proteins) gene might exert an independent effect on the development of Diabetic retinopathy.
An association has been found between the TXNIP gene methylation pattern and type 2 diabetes mellitus in ischemic stroke patients through epigenetic mechanisms, related to sustained hyperglycemia levels with HbA1c >/= 7%.
These findings thereby provide new mechanistic insight into the regulation of TXNIP and beta-cell biology and reveal novel links between proinflammatory cytokines, carbohydrate response element binding protein (show MLXIPL Proteins)-mediated transcription, and microRNA signaling.
The crystal structure of the complex between a phosphorylated PPxY motif of TXNIP and the SH2 domain of Vav2 reveals a conserved recognition mechanism.
Activation of the miR (show MLXIP Proteins)-373-TXNIP-HIF1alpha (show HIF1A Proteins)-TWIST signaling axis is correlated with a worse outcome in patients with breast cancer.
Metformin down-regulates high-glucose-induced TXNIP transcription by inactivating ChREBP (show MLXIPL Proteins) and FOXO1 (show FOXO1 Proteins) in endothelial cells, partially through AMP-activated protein kinase (show PRKAA2 Proteins) activation
Foam cell-released 4-hydroxnonenal activates PPARdelta (show PPARD Proteins) in Vascular endothelial cells, leading to increased TXNIP expression and consequently to senescence.
our data support the hypothesis that TXNIP is an effective target for the treatment of breast cancer.
Expression of TXNIP was up-regulated in all three NSCLC cell lines.
The molecular characterization of porcine TXNIP gene, is described.
single-marker and haplotype analyses revealed significant effects of TXNIP on hot carcass weight, test daily gain, and lifetime daily gain
Diabetes induces TXNIP expressions at mRNA levels, but shows the opposite effect on GS.
ITCH targets TXNIP for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (show TXN Proteins) system.
Txnip plays an important role in oxidative inflammatory response and atherosclerotic lesion development in ApoE (show APOE Proteins) knockout mice.
The results indicate that a lack of TxNIP protects against diabetic nephropathy (DN) and support in vitro data that upregulation of TxNIP by glucose is a key mediator of early oxidative stress and a trigger for the development and progression of DN.
Reactive oxygen species regulation through REDD1 (show DDIT4 Proteins)/TXNIP is physiological rheostat controlling stress-induced autophagy.
These findings suggest that TXNIP is required for endothelial cell survival and homeostasis especially under stress conditions including hyperoxia.
HG-induced NADPH oxidase (show NOX1 Proteins) activation is driven by TXNIP which subsequently triggers NALP3 (show NLRP3 Proteins) inflammasome activation in podocytes and ultimately led to podocyte injury
Data indicate that thioredoxin-interacting protein (TXNIP)levels are induced in erythroid differentiation.
regulates thioredoxin to play an important role in the preservation of cellular viability
thioredoxin interacting protein
, Thioredoxin-interacting protein
, thioredoxin binding protein 2
, thioredoxin-binding protein 2
, thioredoxin-interacting protein
, upregulated by 1,25-dihydroxyvitamin D-3
, vitamin D3 up-regulated protein 1
, hyperlipidemia 1
, thioredoxin binding protein-2