You are viewing an incomplete version of our website. Please click to reload the website as full version.

Thioredoxin Reductase 2 Proteins (TXNRD2)

Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. Additionally we are shipping Thioredoxin Reductase 2 Antibodies (58) and Thioredoxin Reductase 2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TXNRD2 10587 Q9NNW7
TXNRD2 26462 Q9JLT4
Rat TXNRD2 TXNRD2 50551 Q9Z0J5
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Thioredoxin Reductase 2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,386.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   500 μg Log in to see 3 to 4 Days
$328.21
Details

TXNRD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for Thioredoxin Reductase 2 (TXNRD2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Thioredoxin Reductase 2 (TXNRD2) interaction partners

Human Thioredoxin Reductase 2 (TXNRD2) interaction partners

  1. A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2, ATXN2 (show ATXN2 Proteins), and FOXC1 (show FOXC1 Proteins)

  2. The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for Myocardial infarction in subjects with T2 Diabetes mellitus of Slovenian origin.

  3. Data suggest TXNRD1 (show TXNRD1 Proteins) and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.

  4. Absence of TXNRD2 in humans leads to glucocorticoid deficiency.

  5. Single Nucleotide Polymorphisms in the genes GPX1 (show GPX1 Proteins) (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (show DIO2 Proteins) (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population.

  6. Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS (show ROS1 Proteins), and maintenance of the intracellular redox balance.

  7. Data suggest that dietary factor (selenium supplementation) up-regulates endogenous antioxidant systems and protects trophoblasts from oxidative stress; selenium upregulates GPX1 (glutathione peroxidase 1 (show GPX1 Proteins)) and thioredoxin (show TXN Proteins) reductases (TXNRD1 (show TXNRD1 Proteins); TXNRD2).

  8. A role of GPx2 (show GPX2 Proteins), TrxR2 and TrxR3 (show TXNRD3 Proteins) in proliferation, apoptosis and, therefore, also during cancer development.

  9. No obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to Kashin-Beck disease.

  10. study reveals significant differences between TrxR1 (show TXNRD1 Proteins) and TrxR2 in substrate specificity and metal compound inhibition in vitro and in cells

Mouse (Murine) Thioredoxin Reductase 2 (TXNRD2) interaction partners

  1. Suggest role for Txnrd2 in sustaining heart function during aging and suggest that Txnrd2 may be a modifier of heart failure.

  2. Regulatory link was discovered between mitochondrial Txnrd and the JNK (show MAPK8 Proteins)-PHD2 (show EGLN1 Proteins)-Hif-1alpha (show HIF1A Proteins) axis, which highlights how the loss of Txnrd2 and the resulting altered mitochondrial redox balance impairs tumor growth as well as tumor-related angiogenesis.

  3. Data suggest TXNRD1 (show TXNRD1 Proteins) and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.

  4. The SirT1 (show SIRT1 Proteins) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (show SOD2 Proteins), catalase (show CAT Proteins), peroxiredoxins 3 and 5, thioredoxin 2 (show TXN2 Proteins), thioredoxin reductase 2, and uncoupling protein 2 (show UCP2 Proteins).

  5. Data indicate that mammalian thioredoxin reductase (H-TrxR) reduces hypothiocyanous acid (HOSCN).

  6. Txnrd2 exerts a crucial function during postischemic reperfusion via thiol regeneration.

  7. Energization of mitochondria increases the antioxidant potential of the TrxR2/Trx2 (show TXN2 Proteins) system and that inhibition of TrxR2 results in increased H(2)O(2) emission.

  8. Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial TrxR2 gene

  9. Neither Trx2 (show TXN2 Proteins) nor TrxR2 gain of function modified the redox regulation of mitochondria-dependent apoptosis in cos-7 cells, Hela cells and Mouse Neuro2a cells.

  10. Cardiac tissue-restricted ablation of thioredoxin reductase 2 results in fatal dilated cardiomyopathy

Thioredoxin Reductase 2 (TXNRD2) Protein Profile

Protein Summary

Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.

Gene names and symbols associated with TXNRD2

  • thioredoxin reductase 2 (Trxr-2)
  • thioredoxin reductase 2 (TXNRD2)
  • thioredoxin reductase 2 (Txnrd2)
  • AA118373 protein
  • CG11401 protein
  • Dm-TrxR protein
  • Dmel\\CG11401 protein
  • DmTrx protein
  • DmTrxR-2 protein
  • ESTM573010 protein
  • SELZ protein
  • TGR protein
  • TR protein
  • TR-BETA protein
  • Tr3 protein
  • trxr-2 protein
  • TRXR2 protein
  • Trxrd2 protein

Protein level used designations for TXNRD2

CG11401-PA , Trxr-2-PA , thioredoxin reductase , thioredoxin-reductase-2 , selenoprotein Z , thioredoxin reductase 2, mitochondrial , thioredoxin reductase 3 , thioredoxin reductase TR3 , thioredoxin reductase beta , TR beta

GENE ID SPECIES
40475 Drosophila melanogaster
10587 Homo sapiens
26462 Mus musculus
50551 Rattus norvegicus
282389 Bos taurus
Selected quality suppliers for Thioredoxin Reductase 2 Proteins (TXNRD2)
Did you look for something else?