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Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.
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thrombin (show F2 Antibodies)/PAR-1 (show MARK2 Antibodies) interaction regulated MCP-1 (show CPT1B Antibodies), TF, MCSF (show CSF1 Antibodies) and IL-6 (show IL6 Antibodies) production.
Observations illustrate the role of thrombin (show F2 Antibodies) as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 Antibodies) nanoparticle therapeutics.
Thrombin (show F2 Antibodies)-PAR1 (show F2R Antibodies) signaling, via nitric oxide and EPCR (show PROCR Antibodies), promotes hematopoietic stem cell (HSC (show FUT1 Antibodies)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.
thrombin (show F2 Antibodies)/PAR1 (show F2R Antibodies) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.
High Factor IIa expression is associated with multiorgan pathologies in sickle cell disease.
Blockage of thrombin (show F2 Antibodies) exosites with compounds specific for exosite I (hirudin and HD1 (show HDAC1 Antibodies) aptamer) or exosite II (heparin and HD22 aptamer) impaired the COMP (show COMP Antibodies)-thrombin (show F2 Antibodies) interaction, indicating a 2-site binding mechanism.
Whole blood thrombin (show F2 Antibodies) generation assay is capable of detecting a prothrombotic phenotype in Bmal1 (show ARNTL Antibodies)-KO mice.
Fyn (show FYN Antibodies), but not Lyn (show LYN Antibodies), was required for complete Pyk2 (show PTK2B Antibodies) phosphorylation by thrombin (show F2 Antibodies).
the weaker rapid interaction between prothrombin (show F2 Antibodies) and membranes is the most important in vivo when considering the activation of prothrombin (show F2 Antibodies) at the cell surface.
novel pyranosic sulfated (show SULF1 Antibodies) arabinan Ab1 exerts its anticoagulant activity on thrombin (show F2 Antibodies) by a mechanism different from those found previously for other sulfated (show SULF1 Antibodies) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin (show F2 Antibodies) enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (show MAPK1 Antibodies), MSK1 (show RPS6KA5 Antibodies), and NF-kappaB (show NFKB1 Antibodies) play important roles in thrombin (show F2 Antibodies)-induced iNOS (show NOS2 Antibodies) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin (show F2 Antibodies) induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (show F2R Antibodies)) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Antibodies)+).
kinetic and structural analysis of interactions between thrombin (show F2 Antibodies) and the Factor XIII (show UGDH Antibodies) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin (show F2 Antibodies) activation
thrombin (show F2 Antibodies) and factor Xa (show F10 Antibodies) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin (show F2 Antibodies) to bovine thrombin (show F2 Antibodies) as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).