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The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. Additionally we are shipping Thrombomodulin Kits (79) and Thrombomodulin Proteins (25) and many more products for this protein.
Showing 10 out of 124 products:
Human Monoclonal Thrombomodulin Primary Antibody for IHC (fro), FACS - ABIN2712107
Xu, Gong, Yang, Awasthi, Boor: Adenovirus-mediated overexpression of glutathione-s-transferase mitigates transplant arteriosclerosis in rabbit carotid allografts. in Transplantation 2010
Show all 6 references for ABIN2712107
Human Monoclonal Thrombomodulin Primary Antibody for FACS - ABIN2663033
Chen, Shyu, Lin, Lei, Lin, Liu, Yeh: Dengue virus induces thrombomodulin expression in human endothelial cells and monocytes in vitro. in The Journal of infection 2009
Show all 5 references for ABIN2663033
Human Monoclonal Thrombomodulin Primary Antibody for ICFC - ABIN2660817
Delvaeye, Noris, De Vriese, Esmon, Esmon, Ferrell, Del-Favero, Plaisance, Claes, Lambrechts, Zoja, Remuzzi, Conway: Thrombomodulin mutations in atypical hemolytic-uremic syndrome. in The New England journal of medicine 2009
Show all 4 references for ABIN2660817
Human Monoclonal Thrombomodulin Primary Antibody for Func, FACS - ABIN1105881
Dömötör, Benzakour, Griffin, Yule, Fukudome, Zlokovic: Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. in Blood 2003
Show all 2 references for ABIN1105881
Human Monoclonal Thrombomodulin Primary Antibody for IHC (fro), FACS - ABIN784685
Drake, Loke: Isolation of endothelial cells from human first trimester decidua using immunomagnetic beads. in Human reproduction (Oxford, England) 1992
Human Polyclonal Thrombomodulin Primary Antibody for ELISA, WB - ABIN1451724
Wen, Dittman, Ye, Deaven, Majerus, Sadler: Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. in Biochemistry 1987
Decreased thrombomodulin expression in preeclampsia may play a role in placental dysfunction in preeclampsia and is possibly caused by an angiogenic imbalance. Hypertension and obesity are associated with thrombomodulin downregulation.
The presence of THBD proximal promoter polymorphisms do not explain variations in levels of serum and cell-expressed THBD in premature acute coronary syndrome patients in Bahrain.
the functional relevance of the rs3176123 variation and indicate that higher thrombomodulin expression by individuals with the 2729C allele likely accounts for their decreased risk for acute GVHD development and subsequent mortality.
The lack of any association between the sTM levels and genetic variants in ARDS suggests that the increased levels of sTM may reflect severity of endothelial damage rather than genetic heterogeneity.
Identified Nur77 (show NR4A1 Antibodies)/Nor1 (show NR4A3 Antibodies) as novel regulators of thrombomodulin expression and function in vascular endothelial cells.
The results of this study supported the association of the epistatic interactions of ALOX5AP (show ALOX5AP Antibodies), THBD, and KNG1 (show KNG1 Antibodies) and present novel evidence for the main effect of KNG1 (show KNG1 Antibodies) gene on IS susceptibility.
The EGF5, 6 domains of thrombomodulin appear to be the major domains for down-regulating the complement system rather than the lectin-like domain during xenogenic stimuli.
A minimal TM fragment consisting of the fourth, fifth, and most of the sixth EGF (show EGF Antibodies)-like domain (TM456m) that has been prepared has much improved solubility, thrombin (show F2 Antibodies) binding capacity, and anticoagulant activity versus those of previous TM456 constructs.
Data indicate that blood dendritic cell antigen 3 BDCA3(+) and C-type lectin (show MBL2 Antibodies) domain family 9, member A (show CXCL14 Antibodies) CLEC9A (show CLEC9A Antibodies)(+) dendritic cells (DC) are of major importance in the induction of anti-viral and anti-tumor immunity.
Recombinant thrombomodulin does not impair neutrophil functions.
TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF (show PDGFA Antibodies)-BB. In addition, rTMD23 has therapeutic potential in corneal injury
Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice
the recombinant epidermal growth factor (show EGF Antibodies)-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice
Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells.
Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 (show HMGB1 Antibodies) and an independent mechanism.
The lectin-like domain of TM does not play an important role in the host response to M. tuberculosis infection in mice.
Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.
TM's lectin-like domain constrains glucose-induced complement activation on endothelial cells and podocytes and ameliorates albuminuria and glomerular damage.
FFAs inhibit TM-EPCR (show PROCR Antibodies)-Protein C (show PROC Antibodies) system in endothelial cells through activating JNK (show MAPK8 Antibodies) signaling, which may be a mechanism for the prothrombotic state in metabolic syndrome.
Atorvastin induces THBD expression in the aorta of cholesterol-fed rabbits.
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
, CD141 antigen
, snoRNA MBII-339