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The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. Additionally we are shipping Thrombomodulin Antibodies (125) and Thrombomodulin Kits (79) and many more products for this protein.
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Decreased thrombomodulin expression in preeclampsia may play a role in placental dysfunction in preeclampsia and is possibly caused by an angiogenic imbalance. Hypertension and obesity are associated with thrombomodulin downregulation.
The presence of THBD proximal promoter polymorphisms do not explain variations in levels of serum and cell-expressed THBD in premature acute coronary syndrome patients in Bahrain.
the functional relevance of the rs3176123 variation and indicate that higher thrombomodulin expression by individuals with the 2729C allele likely accounts for their decreased risk for acute GVHD development and subsequent mortality.
The lack of any association between the sTM levels and genetic variants in ARDS suggests that the increased levels of sTM may reflect severity of endothelial damage rather than genetic heterogeneity.
Identified Nur77 (show NR4A1 Proteins)/Nor1 (show NR4A3 Proteins) as novel regulators of thrombomodulin expression and function in vascular endothelial cells.
The results of this study supported the association of the epistatic interactions of ALOX5AP (show ALOX5AP Proteins), THBD, and KNG1 (show KNG1 Proteins) and present novel evidence for the main effect of KNG1 (show KNG1 Proteins) gene on IS susceptibility.
The EGF5, 6 domains of thrombomodulin appear to be the major domains for down-regulating the complement system rather than the lectin-like domain during xenogenic stimuli.
A minimal TM fragment consisting of the fourth, fifth, and most of the sixth EGF (show EGF Proteins)-like domain (TM456m) that has been prepared has much improved solubility, thrombin (show F2 Proteins) binding capacity, and anticoagulant activity versus those of previous TM456 constructs.
Data indicate that blood dendritic cell antigen 3 BDCA3(+) and C-type lectin (show MBL2 Proteins) domain family 9, member A (show CXCL14 Proteins) CLEC9A (show CLEC9A Proteins)(+) dendritic cells (DC) are of major importance in the induction of anti-viral and anti-tumor immunity.
Recombinant thrombomodulin does not impair neutrophil functions.
TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF (show PDGFA Proteins)-BB. In addition, rTMD23 has therapeutic potential in corneal injury
Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice
the recombinant epidermal growth factor (show EGF Proteins)-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice
Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells.
Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 (show HMGB1 Proteins) and an independent mechanism.
The lectin-like domain of TM does not play an important role in the host response to M. tuberculosis infection in mice.
Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.
TM's lectin-like domain constrains glucose-induced complement activation on endothelial cells and podocytes and ameliorates albuminuria and glomerular damage.
FFAs inhibit TM-EPCR (show PROCR Proteins)-Protein C (show PROC Proteins) system in endothelial cells through activating JNK (show MAPK8 Proteins) signaling, which may be a mechanism for the prothrombotic state in metabolic syndrome.
Atorvastin induces THBD expression in the aorta of cholesterol-fed rabbits.
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
, CD141 antigen
, snoRNA MBII-339