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The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. Additionally we are shipping Thrombomodulin Kits (88) and Thrombomodulin Proteins (23) and many more products for this protein.
Showing 10 out of 252 products:
Human Monoclonal Thrombomodulin Primary Antibody for IHC (fro), FACS - ABIN2712107
Xu, Gong, Yang, Awasthi, Boor: Adenovirus-mediated overexpression of glutathione-s-transferase mitigates transplant arteriosclerosis in rabbit carotid allografts. in Transplantation 2010
Show all 6 references for ABIN2712107
Human Monoclonal Thrombomodulin Primary Antibody for ICFC - ABIN2660817
Chen, Shyu, Lin, Lei, Lin, Liu, Yeh: Dengue virus induces thrombomodulin expression in human endothelial cells and monocytes in vitro. in The Journal of infection 2009
Show all 4 references for ABIN2660817
Mouse (Murine) Polyclonal Thrombomodulin Primary Antibody for FACS, ICC - ABIN4899312
Schmidt, Yang, Janssen, Gandjeva, Perez, Barthel, Zemans, Bowman, Koyanagi, Yunt, Smith, Cheng, Overdier, Thompson, Geraci, Douglas, Pearse, Tuder: The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. in Nature medicine 2013
Show all 3 references for ABIN4899312
Human Monoclonal Thrombomodulin Primary Antibody for Func, FACS - ABIN1105881
Dömötör, Benzakour, Griffin, Yule, Fukudome, Zlokovic: Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. in Blood 2003
Show all 2 references for ABIN1105881
Mouse (Murine) Monoclonal Thrombomodulin Primary Antibody for FACS - ABIN4895906
Geiger, Pawar, Kerschen, Nattamai, Hernandez, Liang, Fernández, Cancelas, Ryan, Kustikova, Schambach, Fu, Wang, Fink, Petersen, Zhou, Griffin, Baum, Weiler, Hauer-Jensen: Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. in Nature medicine 2012
Human Polyclonal Thrombomodulin Primary Antibody for ELISA, WB - ABIN1451724
Wen, Dittman, Ye, Deaven, Majerus, Sadler: Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. in Biochemistry 1987
Mouse (Murine) Monoclonal Thrombomodulin Primary Antibody for FACS, ICC - ABIN4899313
Belcher, Chen, Nguyen, Milbauer, Abdulla, Alayash, Smith, Nath, Hebbel, Vercellotti: Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. in Blood 2014
Human Monoclonal Thrombomodulin Primary Antibody for FACS - ABIN4896077
Silk, Silk, Ichiryu, Davies, Nolan, Leishman, Carpenter, Watt, Cerundolo, Fairchild: Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. in Gene therapy 2012
The results demonstrate that the LFA-1 (show ITGAL Antibodies) and Mac-1 (show ITGAM Antibodies) integrins on leukocytes bind to thrombomodulin (TM), thereby establishing the molecular and structural basis underlying LFA-1 (show ITGAL Antibodies) and Mac-1 (show ITGAM Antibodies) integrin interaction with TM on endothelial cells.
Human thrombomodulin transgenic aortic endothelial cells are less sensitive to activation by either HMGB1 or hTNFalpha, an effect that appears to be dependent on the lectin-like domain of TBM.
In placenta of patients with preeclampsia, we detected abnormal expression of F3 and THBD with increased protein and mRNA levels. The role of these molecules in the pathogenesis of this disease and in alterations of hemostatic and histopathological aspects of placentas need further studying.
TM up-regulated E-cadherin (show CDH1 Antibodies) but down-regulated N-cadherin (show CDH2 Antibodies) expression, resulting in reversal of epithelial-mesenchymal transition (EMT (show ITK Antibodies)) in the lung cancer cells.
High serum thrombomodulin expression is associated with non-alcoholic fatty liver disease.
results do not suggest a predictive role for THBD c.1418C>T polymorphism in VTE recurrence
R12 (show GPR17 Antibodies) is a critical residue for the activation of TAFI (show CPB2 Antibodies) by thrombin (show F2 Antibodies)-thrombomodulin
Study detected a statistically significant positive correlation between expanded disability status scale scores and thrombomodulin levels (p<0.01) and a 10% positive correlation between expanded disability status scale scores and APC (show APC Antibodies) levels in multiple sclerosis patients
Case Report: thrombotic microangiopathy with mutations in complement factor I (show CFI Antibodies) and thrombomodulin.
increased plasma TM levels and serum hs-CRP (show CRP Antibodies) levels in cerebral infarction (CI) patients were associated with the development of CI in Asians.
the lectin-like domain of thrombomodulin is critically involved in host defence against E. coli induced acute pyelonephritis
Identified Nur77 (show NR4A1 Antibodies)/Nor1 (show NR4A3 Antibodies) as novel regulators of thrombomodulin expression and function in vascular endothelial cells.
TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF (show PDGFA Antibodies)-BB. In addition, rTMD23 has therapeutic potential in corneal injury
Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice
the recombinant epidermal growth factor (show EGF Antibodies)-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice
Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells.
Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 (show HMGB1 Antibodies) and an independent mechanism.
The lectin-like domain of TM does not play an important role in the host response to M. tuberculosis infection in mice.
Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.
TM's lectin-like domain constrains glucose-induced complement activation on endothelial cells and podocytes and ameliorates albuminuria and glomerular damage.
Atorvastin induces THBD expression in the aorta of cholesterol-fed rabbits.
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
, CD141 antigen
, snoRNA MBII-339