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The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. Additionally we are shipping Thrombomodulin Kits (98) and Thrombomodulin Proteins (25) and many more products for this protein.
Showing 10 out of 291 products:
Human Polyclonal Thrombomodulin Primary Antibody for WB - ABIN2801892
Suzuki, Kusumoto, Deyashiki, Nishioka, Maruyama, Zushi, Kawahara, Honda, Yamamoto, Horiguchi: Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. in The EMBO journal 1987
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Mouse (Murine) Polyclonal Thrombomodulin Primary Antibody for CyTOF, FACS - ABIN4899312
Schmidt, Yang, Janssen, Gandjeva, Perez, Barthel, Zemans, Bowman, Koyanagi, Yunt, Smith, Cheng, Overdier, Thompson, Geraci, Douglas, Pearse, Tuder: The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. in Nature medicine 2013
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Human Monoclonal Thrombomodulin Primary Antibody for FACS, WB - ABIN2192010
Dömötör, Benzakour, Griffin, Yule, Fukudome, Zlokovic: Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. in Blood 2003
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Human Monoclonal Thrombomodulin Primary Antibody for WB - ABIN2192009
Tsuneyoshi, Fukudome, Higuchi, Kimoto: Preparation and characterization of monoclonal antibodies to thrombomodulin. in Hybridoma (2005) 2005
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Human Monoclonal Thrombomodulin Primary Antibody for IHC (fro), FACS - ABIN2478498
Drake, Loke: Isolation of endothelial cells from human first trimester decidua using immunomagnetic beads. in Human reproduction (Oxford, England) 1992
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Mouse (Murine) Monoclonal Thrombomodulin Primary Antibody for FACS - ABIN4895906
Geiger, Pawar, Kerschen, Nattamai, Hernandez, Liang, Fernández, Cancelas, Ryan, Kustikova, Schambach, Fu, Wang, Fink, Petersen, Zhou, Griffin, Baum, Weiler, Hauer-Jensen: Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. in Nature medicine 2012
Mouse (Murine) Monoclonal Thrombomodulin Primary Antibody for CyTOF, FACS - ABIN4899313
Belcher, Chen, Nguyen, Milbauer, Abdulla, Alayash, Smith, Nath, Hebbel, Vercellotti: Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. in Blood 2014
Human Monoclonal Thrombomodulin Primary Antibody for FACS - ABIN4896076
Silk, Silk, Ichiryu, Davies, Nolan, Leishman, Carpenter, Watt, Cerundolo, Fairchild: Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. in Gene therapy 2012
Human Monoclonal Thrombomodulin Primary Antibody for FM, IHC (fro) - ABIN2688974
Teasdale, Bird, Bird: Internalization of the anticoagulant thrombomodulin is constitutive and does not require a signal in the cytoplasmic domain. in Immunology and cell biology 1995
The finding of a previously unrecognized fibrinolytic phenotype indicates that bleeding in Thrombomodulin-associated coagulopathy has a complex pathogenesis and highlights the pivotal role of TM as a regulator of hemostasis.
TM mediates cell proliferation and migration via the Epithelial-To-Mesenchymal Transition (EMT (show ITK Antibodies)) biomarkercyclooxygenase (COX)-2 (show COX2 Antibodies)
the whole THBD gene sequenced in patients with recurrent venous thromboembolism (VTE); found 8 polymorphisms in the THBD gene in Swedish population; none of these polymorphisms was significantly associated with the risk of VTE recurrence; results indicate that THBD polymorphisms may not be a risk factor for VTE recurrence
CORM-2 protects human umbilical vein endothelial cells from lipopolysaccharide-induced injury, by way of suppressing NF-kappaB (show NFKB1 Antibodies) activity, which downregulates TM and EPCR (show PROCR Antibodies) mRNAs. It also decreases MMP-2 (show MMP2 Antibodies) expression and prevents the shedding of TM and EPCR (show PROCR Antibodies) from the surface of endothelial cells, so as to preserve their protective effect.
The results demonstrate that the LFA-1 (show ITGAL Antibodies) and Mac-1 (show ITGAM Antibodies) integrins on leukocytes bind to thrombomodulin (TM), thereby establishing the molecular and structural basis underlying LFA-1 (show ITGAL Antibodies) and Mac-1 (show ITGAM Antibodies) integrin interaction with TM on endothelial cells.
Human thrombomodulin transgenic aortic endothelial cells are less sensitive to activation by either HMGB1 or hTNFalpha, an effect that appears to be dependent on the lectin-like domain of TBM.
In placenta of patients with preeclampsia, we detected abnormal expression of F3 and THBD with increased protein and mRNA levels. The role of these molecules in the pathogenesis of this disease and in alterations of hemostatic and histopathological aspects of placentas need further studying.
TM up-regulated E-cadherin (show CDH1 Antibodies) but down-regulated N-cadherin (show CDH2 Antibodies) expression, resulting in reversal of epithelial-mesenchymal transition (EMT (show ITK Antibodies)) in the lung cancer cells.
High serum thrombomodulin expression is associated with non-alcoholic fatty liver disease.
results do not suggest a predictive role for THBD c.1418C>T polymorphism in VTE recurrence
the lectin-like domain of thrombomodulin is critically involved in host defence against E. coli induced acute pyelonephritis
Identified Nur77 (show NR4A1 Antibodies)/Nor1 (show NR4A3 Antibodies) as novel regulators of thrombomodulin expression and function in vascular endothelial cells.
TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF (show PDGFA Antibodies)-BB. In addition, rTMD23 has therapeutic potential in corneal injury
Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice
the recombinant epidermal growth factor (show EGF Antibodies)-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice
Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells.
Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 (show HMGB1 Antibodies) and an independent mechanism.
The lectin-like domain of TM does not play an important role in the host response to M. tuberculosis infection in mice.
Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.
TM's lectin-like domain constrains glucose-induced complement activation on endothelial cells and podocytes and ameliorates albuminuria and glomerular damage.
Atorvastin induces THBD expression in the aorta of cholesterol-fed rabbits.
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
, CD141 antigen
, snoRNA MBII-339