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Promotes FBN1 matrix assembly. Additionally we are shipping Thrombospondin, Type I, Domain Containing 4 Kits (1) and many more products for this protein.
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In breast cancer, some GATA3 (show GATA3 Proteins) effects shift from tumor suppressing to tumor promoting during tumorigenesis, with deregulation of three genes, BCL2 (show BCL2 Proteins), DACH1 (show DACH1 Proteins), THSD4, representing major GATA3 (show GATA3 Proteins)-controlled processes in cancer progression.
ADAMTSL6beta has a role in fibrillin-1 (show FBN1 Proteins) microfibril formation
THSD4 polymorphism was not found to be associated with COPD (show ARCN1 Proteins) risk
Data show expression of TNS1, GSTCD, AGER (show AGER Proteins), HTR4 (show HTR4 Proteins) and THSD4 in lung tissue and indicate potential targets for interventions to alleviate respiratory disease.
Results indicated that ADAMTSL-6 is a novel microfibril-associated protein that binds directly to fibrillin-1 (show FBN1 Proteins) and promotes fibrillin-1 (show FBN1 Proteins) matrix assembly.
Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN.
A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6
, ADAMTS-like protein 6
, thrombospondin type-1 domain-containing protein 4
, ADAMTS-like protein 4