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The protein encoded by THBS1 is a subunit of a disulfide-linked homotrimeric protein. Additionally we are shipping Thrombospondin 1 Antibodies (173) and Thrombospondin 1 Kits (47) and many more products for this protein.
Showing 10 out of 28 products:
ELL (show ELL Proteins) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
Circulating TSP-1 levels decrease up to 24 months prior to diagnosis of PDAC and significantly enhance the diagnostic performance of CA19-9. The influence of diabetes mellitus on biomarker behavior should be considered in future studies.
Crisp2 (show CRISP2 Proteins) genetic defects in sperm from humans and mice result in male infertility.
F-actin dynamics modulate the patterning of TSP1 in extracellular matrix and that TSP1 oligomer state is a key determinant of this process.
TSP-1 regulates multiple microRNAs in VSMCs adding a new layer of complexity to TSP-1 regulation of VSMC function
quercetin could increase TSP-1 expression to inhibit angiogenesis resulting in antagonizing prostate cancer PC-3 (show PCSK1 Proteins) cell and xenograft tumor growth
The anti-angiogenic activity of the native TSP-1 active fragment was maintained in the new TSP-1 mimetics and the results provide a new chemical approach for the design of TSP-1 mimetics.
In the current study Factor V Leiden (show F5 Proteins), prothrombin (show F2 Proteins) G20210A, and thrombospondin-1 polymorphisms showed no association with severity of hepatic fibrosis.
Triptolide can down regulates the expression of thrombospondin 1 and TGF-beta-1 (show TGFB1 Proteins) in renal tubular cells. This plays a role in the pathogenesis of renal tubular fibrosis.
increased plasma thrombospondin-1 concentrations following ICH (show COL4a2 Proteins) are independently associated with injury severity and short-term and long-term clinical outcomes
Novel role of TNFalpha (show TNF Proteins) in inducing inflammatory stress response in human microvascular endothelial cells through Akt (show AKT1 Proteins)- and P38 MAPK (show MAPK14 Proteins)-mediated expression of TSP-1, independent of NFkappaB (show NFKB1 Proteins) signaling.
Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (show THBS2 Proteins) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (show THBS2 Proteins), up-regulates expression of FGF2 (fibroblast growth factor 2 (show FGF2 Proteins)).
Thrombospondin has a role in inducing RhoA (show RHOA Proteins) inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly
Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (show INS Proteins)-like growth factor
The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications
The novel finding that TSP-1-induced migration is dependent on the CD44 (show CD44 Proteins) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (show KDM5D Proteins)).
Data indicate that thrombospondin-1 may contribute to a destructive macrophage response in dysferlinopathy and pose the intriguing possibility that thrombospondin-1 levels may serve as a biomarker for disease progression.
demonstrate that HIF-2alpha (show EPAS1 Proteins) is clearly implicated in the TSP1 (show GZMA Proteins) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction
Thrombospondin-1 was differentially expressed according to tumor grade, but not affected by p53 (show TP53 Proteins) expression or mutational status
Data suggest neutrophil protease- Tsp-1 (thrombospondin-1) axis as a potential antimetastatic therapeutic target.
These results contribute new insights on the controversial role of TSP-1 (show GZMA Proteins) in cancer.
TSP1 (show GZMA Proteins) contributes to progression of chronic kidney disease by catalyzing activation of latent TGF-beta1 (show TGFB1 Proteins), resulting in promotion of a fibroproliferative response over an inflammatory response.
Thrombospondin1 deficiency did not affect the development of obesity associated macro-vascular complication in ApoE (show APOE Proteins)-/- mice, but attenuated obesity associated micro-vascular complications.
Thrombospondin-1 expression plays a significant role in regulation of migration and adhesion of mononuclear cells, contributing to vascular inflammation during AAA (show AAAS Proteins) development.
findings prove that the TSP-1 (show GZMA Proteins)/CD47 (show CD47 Proteins)/SIRP (show SIRPA Proteins)-alpha signal axis is important to the evolution of tumor cells in the microenvironment of immunotherapy and identify thrombospondin-1 as a key signal
ADAMTS-7 (show ADAMTS7 Proteins) was directly associated with thrombospondin-1 by its C terminus and degraded thrombospondin-1 in vivo and in vitro. The inhibitory effect of ADAMTS-7 (show ADAMTS7 Proteins) on postinjury endothelium recovery was circumvented in Tsp1 (show GZMA Proteins)(-/-) mice.
These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (show IGF1 Proteins) and the mechanisms by which hyperglycemia regulates TSP-1 protein.
Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (show TGFB1 Proteins) expression.
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
, cancer/testis antigen 36
, glyceraldehyde-3-phosphate dehydrogenase-like 5
, testis specific protein 1 (probe H4-1 p3-1)
, testis-specific protein TPX-1