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The protein encoded by THBS1 is a subunit of a disulfide-linked homotrimeric protein. Additionally we are shipping Thrombospondin 1 Antibodies (175) and Thrombospondin 1 Kits (48) and many more products for this protein.
Showing 10 out of 28 products:
ELL (show ELL Proteins) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
quercetin could increase TSP-1 expression to inhibit angiogenesis resulting in antagonizing prostate cancer PC-3 (show PCSK1 Proteins) cell and xenograft tumor growth
The anti-angiogenic activity of the native TSP-1 active fragment was maintained in the new TSP-1 mimetics and the results provide a new chemical approach for the design of TSP-1 mimetics.
In the current study Factor V Leiden (show F5 Proteins), prothrombin (show F2 Proteins) G20210A, and thrombospondin-1 polymorphisms showed no association with severity of hepatic fibrosis.
Triptolide can down regulates the expression of thrombospondin 1 and TGF-beta-1 (show TGFB1 Proteins) in renal tubular cells. This plays a role in the pathogenesis of renal tubular fibrosis.
increased plasma thrombospondin-1 concentrations following ICH (show COL4a2 Proteins) are independently associated with injury severity and short-term and long-term clinical outcomes
Novel role of TNFalpha (show TNF Proteins) in inducing inflammatory stress response in human microvascular endothelial cells through Akt (show AKT1 Proteins)- and P38 MAPK (show MAPK14 Proteins)-mediated expression of TSP-1, independent of NFkappaB (show NFKB1 Proteins) signaling.
Plasma thrombospondin-1 concentrations are elevated obviously and are highly associated with long-term outcome of ischemic stroke
TSP1 up regulation might be critically involved in the disease progression with rheumatoid arthritis.
The THBS1 N700S polymorphism was associated with coronary artery disease risk.
DLL4 (show DLL4 Proteins)/Notch1 (show NOTCH1 Proteins) and BMP9 (show GDF2 Proteins) interdependent signaling induces endothelial cell quiescence via P27KIP1 (show CDKN1B Proteins)/thrombospondin pathway.
Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (show THBS2 Proteins) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (show THBS2 Proteins), up-regulates expression of FGF2 (fibroblast growth factor 2 (show FGF2 Proteins)).
Thrombospondin has a role in inducing RhoA (show RHOA Proteins) inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly
Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (show INS Proteins)-like growth factor
The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications
The novel finding that TSP-1-induced migration is dependent on the CD44 (show CD44 Proteins) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (show KDM5D Proteins)).
demonstrate that HIF-2alpha (show EPAS1 Proteins) is clearly implicated in the TSP1 (show GZMA Proteins) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction
Thrombospondin-1 was differentially expressed according to tumor grade, but not affected by p53 (show TP53 Proteins) expression or mutational status
Data suggest neutrophil protease- Tsp-1 (thrombospondin-1) axis as a potential antimetastatic therapeutic target.
These results contribute new insights on the controversial role of TSP-1 (show GZMA Proteins) in cancer.
TSP1 (show GZMA Proteins) contributes to progression of chronic kidney disease by catalyzing activation of latent TGF-beta1 (show TGFB1 Proteins), resulting in promotion of a fibroproliferative response over an inflammatory response.
Thrombospondin1 deficiency did not affect the development of obesity associated macro-vascular complication in ApoE (show APOE Proteins)-/- mice, but attenuated obesity associated micro-vascular complications.
Thrombospondin-1 expression plays a significant role in regulation of migration and adhesion of mononuclear cells, contributing to vascular inflammation during AAA (show AAAS Proteins) development.
findings prove that the TSP-1 (show GZMA Proteins)/CD47 (show CD47 Proteins)/SIRP (show SIRPA Proteins)-alpha signal axis is important to the evolution of tumor cells in the microenvironment of immunotherapy and identify thrombospondin-1 as a key signal
ADAMTS-7 (show ADAMTS7 Proteins) was directly associated with thrombospondin-1 by its C terminus and degraded thrombospondin-1 in vivo and in vitro. The inhibitory effect of ADAMTS-7 (show ADAMTS7 Proteins) on postinjury endothelium recovery was circumvented in Tsp1 (show GZMA Proteins)(-/-) mice.
Thrombospondin-1 and CD47 (show CD47 Proteins) signaling regulate healing of thermal injury in mice.
These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (show IGF1 Proteins) and the mechanisms by which hyperglycemia regulates TSP-1 protein.
Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (show TGFB1 Proteins) expression.
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
, cancer/testis antigen 36
, glyceraldehyde-3-phosphate dehydrogenase-like 5
, testis specific protein 1 (probe H4-1 p3-1)
, testis-specific protein TPX-1