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The protein encoded by THBS4 belongs to the thrombospondin protein family. Additionally we are shipping Thrombospondin 4 Antibodies (48) and Thrombospondin 4 Kits (21) and many more products for this protein.
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The THBS4 A387P polymorphism was associated with coronary artery disease in American population.
Tsp4 functions as an ECM (show MMRN1 Proteins) scaffold at myotendinous (show TNC Proteins) junctions, with potential therapeutic uses in tendon strengthening and repair
THBS4 expression in breast cancer-associated extracellular matrix contributes to the activated stromal response exhibited during tumour progression
the balancing selection target in THBS4 is likely represented by one or more variants that regulate tissue-specific and sex-specific gene expression
The results of thid study suggested that injury-induced spinal TSP4 may contribute to spinal presynaptic hypersensitivity and neuropathic pain states.
genetic polymorphism predicts cardiovascular risk in postinfarction patients with high HDL (show HSD11B1 Proteins) cholesterol and C-reactive protein (show CRP Proteins) levels
Identify THBS4 as a powerful marker for diffuse-type gastric adenocarcinomas and to provide an initial characterization of its expression in the course of this disease.
High THBS4 methylation resulting in inactivation of the gene is associated with colorectal cancer.
thrombospondin-4 C-terminal peptide has a role in stimulating erythroid cell proliferation
Promoter hypermethylation of thrombospondin 4 is associated with cutaneous T-cell lymphoma
present studies on the cardiac function of KLF6 (show KLF6 Proteins) show a new mechanism whereby cardiomyocytes regulate cardiac fibrosis through transcriptional control of the extracellular matrix factor thrombospondin 4
these data identify the critical intracellular functional domains of thrombospondin-4, which was formerly thought to have only extracellular functions
TSP-4, an extracellular matrix protein previously associated with tissue remodeling, is now demonstrated to possess proangiogenic activity.
This study demonistrated that Thrombospondin 4 deficiency in mouse impairs neuronal migration in the early postnatal and adult brain.
thrombospondin-4 is downregulated by curcumin-induced oxidized low-density lipoprotein in mouse macrophages
findings have important implications for post-injury applications of endogenous and transplanted neural stem cells in the therapeutic setting, as well as disease states where Thbs (show THBS1 Proteins) family members have important roles
The expression of inflammatory and fibrotic genes known to be influential in myocardial remodeling changed as a result of TSP-4 deficiency in vivo and as a result of incubation of cells with recombinant TSP-4 in vitro.
Thbs4 cardiac-specific transgenic mice were protected from myocardial injury, whereas Thbs4-/- mice were sensitized to cardiac maladaptation.
TSP4 is myocyte-interstitial mechano-signaling molecule central to adaptive cardiac contractile responses to acute stress, which appears to play a crucial role in the transition to chronic cardiac dilatation and failure.
Thrombospondin-4 plays an important role in the local regulation of inflammation associated with atherogenesis.
Thrombospondin-4 widely distributed in bovine eye where it may play role in functions of basement membranes in various tissues. Abundant in trabecular and uveo-scleral pathways. May play role in regulation of aqueous outflow resistance.
The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.