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TBXA2R encodes a member of the G protein-coupled receptor family. Additionally we are shipping Thromboxane A2 Receptor Kits (15) and Thromboxane A2 Receptor Proteins (3) and many more products for this protein.
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Thromboxane A2 receptor is expressed in both vagal and spinal neurons. Thromboxane A(2) may elicit stronger vagal or parasympathetic reflexes in the rabbit when released during tissue trauma depending on the location of release.
Data suggest that in hypoxic pulmonary hypertension, loss of site-specific phosphorylation of TBXA2R results in agonist hyper-responsiveness; Ser324 appears to be primary residue phosphorylated during protein kinase A activation of TBXA2R.
TBXA2R +924C/T polymorphism is associated with asthma risk
A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 (show TBC1D9 Antibodies) C3435T, TBXA2R (rs1131882), and PLA2G7 (show Lp-PLA2 Antibodies) (rs1051931-rs7756935) polymorphisms.
Data suggest that thromboxane A2/TBXA2R signaling promotes multiple myeloma cell proliferation by reducing delay at G2/M phase via up-regulation of MAP kinase (show MAPK1 Antibodies) pathway, up-regulation of cyclin B1 (show CCNB1 Antibodies)/CDK1 (show CDK1 Antibodies) expression, and down-regulation of apoptosis.
The results of this study show that TXA2R polymorphisms may affect platelet function and the risk of developing cerebral ischemia.
TXA2 receptor associated with lipid rafts in platelets is important for functional platelet responses to TXA2
Data suggest TBXA2R requires Ser324 for normal activity; Ser324A mutant is insensitive to activation by protein kinase A/cell hypoxia, has high affinity for agonists (thromboxane A2/analogs), and participates in agonist-induced calcium mobilization.
TXA2 should be regarded as a critical molecule in COX-2 (show COX2 Antibodies)-mediated tumor growth and a valuable target against lung cancer.
Human thromboxane A2 receptor genetic variant V80E exhibited reduced platelet activation whereas A160T demonstrated platelet hyperactivity.
Targeting the TPalpha (show HADHA Antibodies)-TM5 GxxxGxxxL domain may allow development of biased TPalpha (show HADHA Antibodies) homodimer antagonists that avoid suppression of IP-TPalpha (show HADHA Antibodies) heterodimer function.
Non-conservative substitution of E3.49 and E6.30 in prostanoid TP receptor results in superactive mutants that are more efficient in G protein coupling and activation.
Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation.
PKCalpha (show PKCa Antibodies) deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression.
Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism.
Blocking the expression of the thromboxane receptor significantly suppresses the prothrombotic effect of C-reactive protein (show CRP Antibodies).
The thromboxane A(2) receptor agonist 11-deoxy PGF (show PTGFR Antibodies)(2alpha) can partially alleviate embryo crowding in the Lpar3 (show LPAR3 Antibodies)((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3 (show LPAR3 Antibodies)((-/-)) females.
We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow.
thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury
Thromboxane A2 receptor activation via PKC-zeta (show PRKCZ Antibodies)-mediated NAD(P)H (show NQO1 Antibodies) oxidase activation increases superoxide and peroxynitrite, resulting in eNOS (show NOS3 Antibodies) uncoupling in endothelial cells.
thromboxane synthase, prostacyclin synthase (show PTGIS Antibodies) and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition
TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions.
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene.
thromboxane A2 receptor
, prostanoid TP receptor
, TXA2 receptor
, thromboxane prostanoid
, Thromboxane receptor