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TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Additionally we are shipping Thymic Stromal Lymphopoietin Antibodies (123) and Thymic Stromal Lymphopoietin Proteins (42) and many more products for this protein.
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Human TSLP ELISA Kit for Sandwich ELISA - ABIN1672862
Siracusa, Saenz, Hill, Kim, Headley, Doering, Wherry, Jessup, Siegel, Kambayashi, Dudek, Kubo, Cianferoni, Spergel, Ziegler, Comeau, Artis: TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. in Nature 2011
Show all 2 references for ABIN1672862
Mouse (Murine) TSLP ELISA Kit for Sandwich ELISA - ABIN1889375
He, Oyoshi, Garibyan, Kumar, Ziegler, Geha: TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 2 references for ABIN1889375
TSLP expression in the skin is mediated via RARgamma-RXR pathways.
Epidermal thymic stromal lymphopoietin predicts the development of atopic dermatitis during infancy.
study shows that specific food antigens can trigger innate immune mediated esophageal TSLP secretion
production by monocyte-derived dendritic cells requires the integration of signals from dectin-1 (show CLEC7A ELISA Kits), the IL-1 (show IL1A ELISA Kits) receptor, and endoplasmic reticulum stress response stress signaling pathways
The association of TSLP polymorphism rs2289278 with atopic dermatitis (AD) was stronger in children with allergic sensitization than in children without atopy, and TSLP polymorphisms also increased the risk of asthma in children with AD
The positive feedback loop between TSLP, IL-33 (show IL33 ELISA Kits) and their receptors, and Th2 cytokines may facilitate Th2-skewed inflammation in eosinophilic CRSwNP.
results show that rs1837253 polymorphism may be directly involved in the regulation of TSLP secretion.
Upon TSLP stimulation, the cells with the highest TSLPR (show CRLF2 ELISA Kits) expression level showed enhanced proliferation and JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits)-mediated gene regulation in a dose-dependent manner
Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 (show Il3 ELISA Kits) dependent
Correlation between TSLP overexpression and gastric cancer metastasis to lymph nodes indicate that TSLP plays a role in lymph node involvement in gastric cancer patients.
results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers.
Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice
Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand (show TNFSF4 ELISA Kits), thymic stromal lymphopoietin, and IL-33 (show IL33 ELISA Kits)
LIGHT controls TSLP to drive pulmonary fibrosis.
There were no significant differences in clinical scores and numbers of infiltrating eosinophils among IL-25KO, TSLPR (show CRLF2 ELISA Kits) KO, and wild-type mice.
The short TSLP isoform ameliorates experimental colitis in mice and prevents endotoxin shock. The long TSLP isoform is proinflammatory and is only expressed during inflammation.
Suggest that Treg defects in ApoE (show APOE ELISA Kits)(-/-) mice might partially be attributed to the disruption of TSLP-TSLPR (show CRLF2 ELISA Kits)-LAP signaling in epithelial cells and dendritic cells.
expression of, and immune activation by, TSLP contributes significantly to the immunopathology of experimental autoimmune encephalomyelitis.
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
thymic stromal lymphopoietin
, thymic stromal lymphopoetin
, thymic stroma-derived lymphopoietin