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TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Additionally we are shipping Thymic Stromal Lymphopoietin Antibodies (181) and Thymic Stromal Lymphopoietin Kits (76) and many more products for this protein.
Showing 10 out of 42 products:
Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666980
Mazzucchelli, Hixon, Spolski, Chen, Li, Hall, Willette-Brown, Hurwitz, Leonard, Durum: Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. in Blood 2008
Show all 7 references for ABIN2666980
Mouse (Murine) TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2667598
Nguyen, Vanichsarn, Nadeau: TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2010
Show all 7 references for ABIN2667598
Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666676
Omori, Ziegler: Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. in Journal of immunology (Baltimore, Md. : 1950) 2007
Show all 7 references for ABIN2666676
Mouse (Murine) TSLP Protein expressed in Human Cells - ABIN2008516
Liu, Soumelis, Watanabe, Ito, Wang, Malefyt, Omori, Zhou, Ziegler: TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. in Annual review of immunology 2007
Heat stress-induced HSPs can significantly reduce the production and secretion of TSLP from keratinocytes cultured under Th2 environment.
TSLP expression in the skin is mediated via RARgamma-RXR pathways.
Epidermal thymic stromal lymphopoietin predicts the development of atopic dermatitis during infancy.
study shows that specific food antigens can trigger innate immune mediated esophageal TSLP secretion
production by monocyte-derived dendritic cells requires the integration of signals from dectin-1 (show CLEC7A Proteins), the IL-1 (show IL1A Proteins) receptor, and endoplasmic reticulum stress response stress signaling pathways
The association of TSLP polymorphism rs2289278 with atopic dermatitis (AD) was stronger in children with allergic sensitization than in children without atopy, and TSLP polymorphisms also increased the risk of asthma in children with AD
The positive feedback loop between TSLP, IL-33 (show IL33 Proteins) and their receptors, and Th2 cytokines may facilitate Th2-skewed inflammation in eosinophilic CRSwNP.
results show that rs1837253 polymorphism may be directly involved in the regulation of TSLP secretion.
Upon TSLP stimulation, the cells with the highest TSLPR (show CRLF2 Proteins) expression level showed enhanced proliferation and JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins)-mediated gene regulation in a dose-dependent manner
Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 (show Il3 Proteins) dependent
IL-33 (show IL33 Proteins)-ERK (show EPHB2 Proteins)/JNK (show MAPK8 Proteins)/p38 (show CRK Proteins)/Egr-1 (show EGR1 Proteins)/TSLP axis involved in allergic skin Th2 inflammation
Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR (show CRLF2 Proteins)-Ig improves ALI at least in part by regulation of dendritic cell functions.
results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers.
Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice
Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand (show TNFSF4 Proteins), thymic stromal lymphopoietin, and IL-33 (show IL33 Proteins)
LIGHT controls TSLP to drive pulmonary fibrosis.
There were no significant differences in clinical scores and numbers of infiltrating eosinophils among IL-25KO, TSLPR (show CRLF2 Proteins) KO, and wild-type mice.
The short TSLP isoform ameliorates experimental colitis in mice and prevents endotoxin shock. The long TSLP isoform is proinflammatory and is only expressed during inflammation.
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
thymic stromal lymphopoietin
, thymic stromal lymphopoetin
, thymic stroma-derived lymphopoietin