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Thymic Stromal Lymphopoietin Proteins (TSLP)

TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Additionally we are shipping Thymic Stromal Lymphopoietin Antibodies (181) and Thymic Stromal Lymphopoietin Kits (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TSLP 85480 Q969D9
TSLP 53603 Q9JIE6
TSLP 688621  
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Top Thymic Stromal Lymphopoietin Proteins at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 4 pack Log in to see 10 to 12 Days
$86.96
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$201.11
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   4 pack Log in to see 10 to 12 Days
$86.96
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 4 to 6 Days
$533.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$861.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$739.20
Details

TSLP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) , , ,
, ,
Rat (Rattus)

Top referenced Thymic Stromal Lymphopoietin Proteins

  1. Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666980 : Mazzucchelli, Hixon, Spolski, Chen, Li, Hall, Willette-Brown, Hurwitz, Leonard, Durum: Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. in Blood 2008 (PubMed)
    Show all 7 references for ABIN2666980

  2. Mouse (Murine) TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2667598 : Nguyen, Vanichsarn, Nadeau: TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2010 (PubMed)
    Show all 7 references for ABIN2667598

  3. Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666676 : Omori, Ziegler: Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 7 references for ABIN2666676

  4. Mouse (Murine) TSLP Protein expressed in Human Cells - ABIN2008516 : Liu, Soumelis, Watanabe, Ito, Wang, Malefyt, Omori, Zhou, Ziegler: TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. in Annual review of immunology 2007 (PubMed)

More Proteins for Thymic Stromal Lymphopoietin (TSLP) Interaction Partners

Human Thymic Stromal Lymphopoietin (TSLP) interaction partners

  1. Heat stress-induced HSPs can significantly reduce the production and secretion of TSLP from keratinocytes cultured under Th2 environment.

  2. TSLP expression in the skin is mediated via RARgamma-RXR pathways.

  3. Epidermal thymic stromal lymphopoietin predicts the development of atopic dermatitis during infancy.

  4. study shows that specific food antigens can trigger innate immune mediated esophageal TSLP secretion

  5. production by monocyte-derived dendritic cells requires the integration of signals from dectin-1 (show CLEC7A Proteins), the IL-1 (show IL1A Proteins) receptor, and endoplasmic reticulum stress response stress signaling pathways

  6. The association of TSLP polymorphism rs2289278 with atopic dermatitis (AD) was stronger in children with allergic sensitization than in children without atopy, and TSLP polymorphisms also increased the risk of asthma in children with AD

  7. The positive feedback loop between TSLP, IL-33 (show IL33 Proteins) and their receptors, and Th2 cytokines may facilitate Th2-skewed inflammation in eosinophilic CRSwNP.

  8. results show that rs1837253 polymorphism may be directly involved in the regulation of TSLP secretion.

  9. Upon TSLP stimulation, the cells with the highest TSLPR (show CRLF2 Proteins) expression level showed enhanced proliferation and JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins)-mediated gene regulation in a dose-dependent manner

  10. Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 (show Il3 Proteins) dependent

Mouse (Murine) Thymic Stromal Lymphopoietin (TSLP) interaction partners

  1. IL-33 (show IL33 Proteins)-ERK (show EPHB2 Proteins)/JNK (show MAPK8 Proteins)/p38 (show CRK Proteins)/Egr-1 (show EGR1 Proteins)/TSLP axis involved in allergic skin Th2 inflammation

  2. Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR (show CRLF2 Proteins)-Ig improves ALI at least in part by regulation of dendritic cell functions.

  3. TSLP expression in the skin is mediated via RARgamma-RXR pathways.

  4. results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers.

  5. Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice

  6. production by monocyte-derived dendritic cells requires the integration of signals from dectin-1 (show CLEC7A Proteins), the IL-1 (show IL1A Proteins) receptor, and endoplasmic reticulum stress response stress signaling pathways

  7. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand (show TNFSF4 Proteins), thymic stromal lymphopoietin, and IL-33 (show IL33 Proteins)

  8. LIGHT controls TSLP to drive pulmonary fibrosis.

  9. There were no significant differences in clinical scores and numbers of infiltrating eosinophils among IL-25KO, TSLPR (show CRLF2 Proteins) KO, and wild-type mice.

  10. The short TSLP isoform ameliorates experimental colitis in mice and prevents endotoxin shock. The long TSLP isoform is proinflammatory and is only expressed during inflammation.

Thymic Stromal Lymphopoietin (TSLP) Protein Profile

Protein Summary

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with TSLP

  • thymic stromal lymphopoietin (TSLP)
  • thymic stromal lymphopoietin (Tslp)
  • uncharacterized LOC617637 (LOC617637)
  • TSLP protein

Protein level used designations for TSLP

thymic stromal lymphopoietin , thymic stromal lymphopoetin , thymic stroma-derived lymphopoietin

GENE ID SPECIES
706194 Macaca mulatta
737202 Pan troglodytes
100302635 Equus caballus
85480 Homo sapiens
53603 Mus musculus
688621 Rattus norvegicus
101788673 Cavia porcellus
607671 Canis lupus familiaris
617637 Bos taurus
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