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TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Additionally we are shipping Thymic Stromal Lymphopoietin Kits (76) and Thymic Stromal Lymphopoietin Proteins (41) and many more products for this protein.
Showing 10 out of 180 products:
Human Polyclonal TSLP Primary Antibody for ELISA (Capture), WB - ABIN2665475
Mazzucchelli, Hixon, Spolski, Chen, Li, Hall, Willette-Brown, Hurwitz, Leonard, Durum: Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. in Blood 2008
Show all 8 references for 2665475
Human Polyclonal TSLP Primary Antibody for ELISA (Detection) - ABIN2660798
Nguyen, Vanichsarn, Nadeau: TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2010
Show all 7 references for 2660798
Human Polyclonal TSLP Primary Antibody for ELISA, ICC - ABIN258390
Levin, Koelling, Friend, Isaksen, Ziegler, Perlmutter, Farr: Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. in Journal of immunology (Baltimore, Md. : 1950) 1999
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Human Polyclonal TSLP Primary Antibody for EIA, WB - ABIN955356
Angelova-Fischer, Fernandez, Donnadieu, Bulfone-Paus, Zillikens, Fischer, Soumelis: Injury to the stratum corneum induces in vivo expression of human thymic stromal lymphopoietin in the epidermis. in The Journal of investigative dermatology 2010
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Human Polyclonal TSLP Primary Antibody for IHC (p), IHC - ABIN258389
Quentmeier, Drexler, Fleckenstein, Zaborski, Armstrong, Sims, Lyman: Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. in Leukemia 2001
Show all 4 references for 258389
Human Polyclonal TSLP Primary Antibody for IF (p), IHC (p) - ABIN668766
Sakitani, Nonaka, Shibata, Furukawa, Yoshihara: Increased Expression of Thymic Stromal Lymphopoietin and Its Receptor in Kimura's Disease. in ORL; journal for oto-rhino-laryngology and its related specialties 2015
House dust mite exposure increases the expression of TSLP through PI3K/Akt signalin (show CDH1 Antibodies)g pathway in human bronc (show HDAC3 Antibodies)hial epithelial 16HBE cells.
Posttranslational modifications control the functional activity of TSLP in humans and overproduction of TSLP may be a key trigger for the amplification of type 2 inflammation in diseases
Study provides evidence for the hypothesis that TSLP could reflect the histological severity of lumbar disc degeneration (LDD), and TSLP-siRNA and TSLPR (show CRLF2 Antibodies)-siRNA could inhibit apoptosis of nucleus pulposus cells. The evident information obtained from the investigation could lead the way for new therapeutic approaches regarding LDD treatment.
periostin (show POSTN Antibodies)-mediated TSLP production by keratinocytes directly stimulates cutaneous T-cell lymphoma (CTCL) tumor (show EEF1A1 Antibodies) cell growth in addition to inducing a Th2-dominant tumor environment in CTCL (show TSPYL2 Antibodies).
this study shows that TSLP may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase it significantly
Serum TSLP levels were significantly increased in systemic sclerosis patients compared to healthy donors, and were associated with a higher frequency of vasculopathy. The proportion of TSLP-positive dermal cells was increased in the skin of SSc (show CYP11A1 Antibodies) patients compared with healthy donors, and was correlated with fibrosis.
this study shows that NOD2 (show NOD2 Antibodies) is an asthma-related factor that can promote cell proliferation and inflammatory response by mediated expression of TSLP in human airway smooth muscle cells
the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation.
interactions between TSLP in follicular dendritic cells and IgA production in tonsils may be an important mechanism contributing to the pathogenesis of Immunoglobulin A (IgA) nephropathy.
Study demonstrated that naturally occurring severe infections by the most common respiratory viruses in hospitalized infants induce nasal airway secretion of TSLP, IL-33 (show IL33 Antibodies), and periostin (show POSTN Antibodies) when compared with healthy controls
TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin (show CDH1 Antibodies) in house dust mite (HDM (show HDAC3 Antibodies))-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin (show CDH1 Antibodies) and beta-catenin (show CTNNB1 Antibodies) as well as phosphorylation(p)-AKT (show AKT1 Antibodies) induced by HDM (show HDAC3 Antibodies). In vitro, HDM (show HDAC3 Antibodies) increased the expression of TSLP and E-cadherin (show CDH1 Antibodies) dysfunction by PI3K/Akt (show AKT1 Antibodies) signaling pathway.
this study shows that TSLP is a key target of Mi-2beta (show CHD4 Antibodies) in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation
These data demonstrate that multiple pathogenic strains of RSV induce IL-13 (show IL13 Antibodies)-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection.
The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23 (show IL23A Antibodies)/type 17 axes.
this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33 (show IL33 Antibodies), IL-25 (show IL25 Antibodies) and TSLP
TNF-alpha (show TNF Antibodies) and IL-1beta (show IL1B Antibodies), which are partly produced by LPS (show TLR4 Antibodies)-activated leukocytes, contribute to TSLP production via TLR4 (show TLR4 Antibodies) activation in vivo.
IL-33 (show IL33 Antibodies)-ERK (show EPHB2 Antibodies)/JNK (show MAPK8 Antibodies)/p38 (show CRK Antibodies)/Egr-1 (show EGR1 Antibodies)/TSLP axis involved in allergic skin Th2 inflammation
Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR (show CRLF2 Antibodies)-Ig improves ALI at least in part by regulation of dendritic cell functions.
TSLP expression in the skin is mediated via RARgamma-RXR pathways.
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
thymic stromal lymphopoietin
, thymic stromal lymphopoetin
, thymic stroma-derived lymphopoietin