Thymic Stromal Lymphopoietin Proteins (TSLP)

TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Additionally we are shipping Thymic Stromal Lymphopoietin Antibodies (193) and Thymic Stromal Lymphopoietin Kits (77) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TSLP 85480 Q969D9
TSLP 53603 Q9JIE6
TSLP 688621  
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Top Thymic Stromal Lymphopoietin Proteins at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 4 pack Log in to see 10 to 12 Days
$86.96
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$201.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   4 pack Log in to see 10 to 12 Days
$86.96
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 10 μg Log in to see 3 to 4 Days
$85.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$229.85
Details
HOST_Mammalian Cells Mouse Fc Tag   50 μg Log in to see 4 Days
$329.18
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details

TSLP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) , , , ,
, ,
Rat (Rattus)

Top referenced Thymic Stromal Lymphopoietin Proteins

  1. Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666980 : Mazzucchelli, Hixon, Spolski, Chen, Li, Hall, Willette-Brown, Hurwitz, Leonard, Durum: Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. in Blood 2008 (PubMed)
    Show all 7 references for 2666980

  2. Mouse (Murine) TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2667598 : Nguyen, Vanichsarn, Nadeau: TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2010 (PubMed)
    Show all 7 references for 2667598

  3. Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666676 : Omori, Ziegler: Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 7 references for 2666676

  4. Mouse (Murine) TSLP Protein expressed in Human Cells - ABIN2008516 : Liu, Soumelis, Watanabe, Ito, Wang, Malefyt, Omori, Zhou, Ziegler: TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. in Annual review of immunology 2007 (PubMed)

More Proteins for Thymic Stromal Lymphopoietin (TSLP) Interaction Partners

Human Thymic Stromal Lymphopoietin (TSLP) interaction partners

  1. House dust mite exposure increases the expression of TSLP through PI3K/Akt signalin (show CDH1 Proteins)g pathway in human bronc (show HDAC3 Proteins)hial epithelial 16HBE cells.

  2. Posttranslational modifications control the functional activity of TSLP in humans and overproduction of TSLP may be a key trigger for the amplification of type 2 inflammation in diseases

  3. Study provides evidence for the hypothesis that TSLP could reflect the histological severity of lumbar disc degeneration (LDD), and TSLP-siRNA and TSLPR (show CRLF2 Proteins)-siRNA could inhibit apoptosis of nucleus pulposus cells. The evident information obtained from the investigation could lead the way for new therapeutic approaches regarding LDD treatment.

  4. periostin (show POSTN Proteins)-mediated TSLP production by keratinocytes directly stimulates cutaneous T-cell lymphoma (CTCL) tumor (show EEF1A1 Proteins) cell growth in addition to inducing a Th2-dominant tumor environment in CTCL (show TSPYL2 Proteins).

  5. this study shows that TSLP may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase it significantly

  6. Serum TSLP levels were significantly increased in systemic sclerosis patients compared to healthy donors, and were associated with a higher frequency of vasculopathy. The proportion of TSLP-positive dermal cells was increased in the skin of SSc (show CYP11A1 Proteins) patients compared with healthy donors, and was correlated with fibrosis.

  7. this study shows that NOD2 is an asthma-related factor that can promote cell proliferation and inflammatory response by mediated expression of TSLP in human airway smooth muscle cells

  8. the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation.

  9. interactions between TSLP in follicular dendritic cells and IgA production in tonsils may be an important mechanism contributing to the pathogenesis of Immunoglobulin A (IgA) nephropathy.

  10. Study demonstrated that naturally occurring severe infections by the most common respiratory viruses in hospitalized infants induce nasal airway secretion of TSLP, IL-33 (show IL33 Proteins), and periostin (show POSTN Proteins) when compared with healthy controls

Mouse (Murine) Thymic Stromal Lymphopoietin (TSLP) interaction partners

  1. TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin (show CDH1 Proteins) in house dust mite (HDM (show HDAC3 Proteins))-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin (show CDH1 Proteins) and beta-catenin (show CTNNB1 Proteins) as well as phosphorylation(p)-AKT (show AKT1 Proteins) induced by HDM (show HDAC3 Proteins). In vitro, HDM (show HDAC3 Proteins) increased the expression of TSLP and E-cadherin (show CDH1 Proteins) dysfunction by PI3K/Akt (show AKT1 Proteins) signaling pathway.

  2. this study shows that TSLP is a key target of Mi-2beta (show CHD4 Proteins) in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation

  3. These data demonstrate that multiple pathogenic strains of RSV induce IL-13 (show IL13 Proteins)-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection.

  4. the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation.

  5. The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23 (show IL23A Proteins)/type 17 axes.

  6. this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33 (show IL33 Proteins), IL-25 (show IL25 Proteins) and TSLP

  7. TNF-alpha (show TNF Proteins) and IL-1beta (show IL1B Proteins), which are partly produced by LPS (show TLR4 Proteins)-activated leukocytes, contribute to TSLP production via TLR4 (show TLR4 Proteins) activation in vivo.

  8. IL-33 (show IL33 Proteins)-ERK (show EPHB2 Proteins)/JNK (show MAPK8 Proteins)/p38 (show CRK Proteins)/Egr-1 (show EGR1 Proteins)/TSLP axis involved in allergic skin Th2 inflammation

  9. Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR (show CRLF2 Proteins)-Ig improves ALI at least in part by regulation of dendritic cell functions.

  10. TSLP expression in the skin is mediated via RARgamma-RXR pathways.

Thymic Stromal Lymphopoietin (TSLP) Protein Profile

Protein Summary

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with TSLP

  • thymic stromal lymphopoietin (TSLP)
  • thymic stromal lymphopoietin (Tslp)
  • uncharacterized LOC617637 (LOC617637)
  • TSLP protein

Protein level used designations for TSLP

thymic stromal lymphopoietin , thymic stromal lymphopoetin , thymic stroma-derived lymphopoietin

GENE ID SPECIES
706194 Macaca mulatta
737202 Pan troglodytes
100302635 Equus caballus
85480 Homo sapiens
53603 Mus musculus
688621 Rattus norvegicus
101788673 Cavia porcellus
607671 Canis lupus familiaris
617637 Bos taurus
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