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TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Additionally we are shipping Thymic Stromal Lymphopoietin Antibodies (183) and Thymic Stromal Lymphopoietin Kits (76) and many more products for this protein.
Showing 10 out of 40 products:
Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666980
Mazzucchelli, Hixon, Spolski, Chen, Li, Hall, Willette-Brown, Hurwitz, Leonard, Durum: Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. in Blood 2008
Show all 7 references for ABIN2666980
Mouse (Murine) TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2667598
Nguyen, Vanichsarn, Nadeau: TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2010
Show all 7 references for ABIN2667598
Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666676
Omori, Ziegler: Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. in Journal of immunology (Baltimore, Md. : 1950) 2007
Show all 7 references for ABIN2666676
Mouse (Murine) TSLP Protein expressed in Human Cells - ABIN2008516
Liu, Soumelis, Watanabe, Ito, Wang, Malefyt, Omori, Zhou, Ziegler: TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. in Annual review of immunology 2007
While serum TSLP levels were unaffected by concomitant allergies and atopic comorbidities, serum levels of IL-31 (show IL31 Proteins), IL-33 (show IL33 Proteins) and sST2 (show SSTR2 Proteins) were affected to a small extent. We found a positive correlation between TSLP, IL-31 (show IL31 Proteins) and IL-33 (show IL33 Proteins), and an inverse relationship between IL-33 (show IL33 Proteins) and sST2 (show SSTR2 Proteins)
Results showed that TSLP promoted the production of alpha-SMA (show SMN1 Proteins) and collagen I (P<0.001), suggesting that it can accelerate MRC-5 cell fibrosis.
Chronic rhinosinusitis with nasal polyps (CRSwNP) epithelial cells release TSLP and IL-25 (show IL25 Proteins) when stimulated by poly(I:C) but not by DP or AF, suggesting that viral infection may contribute to maintain and amplify the T2 immune response seen in CRSwNP.
TSLP is a key mediator in the pathogenesis of inflammatory bowel diseases and that further studies are needed to evaluate its role. [review]
Letter: report decreased salivary gland TSLP expression in primary Sjogren's syndrome.
A novel mouse xenograft model to study the role of TSLP-induced CRLF2 (show CRLF2 Proteins) signals in normal and malignant human B lymphopoiesis has been developed.
Increased induction and expression of TSLP, IL-25 (show IL25 Proteins), and IL-33 (show IL33 Proteins) from nasal epithelial cells contribute to the pathophysiology of eosinophilic chronic rhinosinusitis.
Heat stress-induced HSPs can significantly reduce the production and secretion of TSLP from keratinocytes cultured under Th2 environment.
TSLP expression in the skin is mediated via RARgamma-RXR pathways.
Epidermal thymic stromal lymphopoietin predicts the development of atopic dermatitis during infancy.
TNF-alpha (show TNF Proteins) and IL-1beta (show IL1B Proteins), which are partly produced by LPS (show TLR4 Proteins)-activated leukocytes, contribute to TSLP production via TLR4 (show TLR4 Proteins) activation in vivo.
IL-33 (show IL33 Proteins)-ERK (show EPHB2 Proteins)/JNK (show MAPK8 Proteins)/p38 (show CRK Proteins)/Egr-1 (show EGR1 Proteins)/TSLP axis involved in allergic skin Th2 inflammation
Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR (show CRLF2 Proteins)-Ig improves ALI at least in part by regulation of dendritic cell functions.
results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers.
Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice
production by monocyte-derived dendritic cells requires the integration of signals from dectin-1 (show CLEC7A Proteins), the IL-1 (show IL1A Proteins) receptor, and endoplasmic reticulum stress response stress signaling pathways
Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand (show TNFSF4 Proteins), thymic stromal lymphopoietin, and IL-33 (show IL33 Proteins)
LIGHT controls TSLP to drive pulmonary fibrosis.
There were no significant differences in clinical scores and numbers of infiltrating eosinophils among IL-25KO, TSLPR (show CRLF2 Proteins) KO, and wild-type mice.
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
thymic stromal lymphopoietin
, thymic stromal lymphopoetin
, thymic stroma-derived lymphopoietin