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catalyzes the transfer of the terminal phosphate of ATP to thymidine to form thymidine 5'-phosphate (dTMP) [RGD, Feb 2006].. Additionally we are shipping Thymidine Kinase 1, Soluble Antibodies (71) and Thymidine Kinase 1, Soluble Kits (28) and many more products for this protein.
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Human TK1 Protein expressed in Escherichia coli (E. coli) - ABIN1098640
Chang, Huang, Chi: Serine 13 is the site of mitotic phosphorylation of human thymidine kinase. in The Journal of biological chemistry 1998
Show all 2 references for ABIN1098640
The down-regulation of Tk1 activity unmasks Tk2 deficiency in Tk2-/- mice and correlates with the onset of mtDNA depletion in the brain and the heart.
blood cells are less dependent on mitochondrial Tk2 compared with several other tissues; these cells can synthesize deoxyribonucleotides required for mtDNA replication by alternative pathways such as phosphorylation of thymidine by cytosolic Tk1
Mutations in the TK1 gene were studied in neonatal transgenic mice treated with AZT.
the small colony mutant phenotype in L5178Y lymphoma is not caused by deletion of both Trp53 (show TP53 Proteins) and thymidine kinase 1
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma (show MOK Proteins) and Radiofrequency Ablation of Metastases to Lung and Liver
TK1 expression is significantly different in invasive urothelial carcinoma and benign urothelium, which underlines its potential as a diagnostic marker
Protein expression of BIRC5 (show BIRC5 Proteins), TK1, and TOP2A (show TOP2A Proteins) in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection.
High Thymidine Kinase expression is associated with adenocarcinoma in Non-small Cell Lung Cancer.
These results demonstrate that there are differences in the specific activities and the subunit compositions of STK1 (show CDK7 Proteins) in hematological malignancies compared with breast and prostate cancer.
A regression analysis showed that only TK1 levels were significant (relative risk (RR)=1.03 for each unit, confidence interval (CI)=1-1.05; p=0.015) for diagnosing a true transformation
We suggest that a chip including DPYD (show DPYD Proteins), TYMS (show TYMS Proteins), TYMP (show TYMP Proteins), TK1, and TK2 genes is a potential tool to predict response in LARC (show CCL20 Proteins) following fluoropyrimidine-based CCRT.
Nuclear TK1 expression in early grade cervical intraepithelial neoplasia predicts risk for progression to malignancy
3'-deoxy-3'-[18F]-fluorothymidine (18F-FLT (show FLT1 Proteins)) kinetics correlates with thymidine kinase-1 expression and cell proliferation in newly diagnosed gliomas
The magnitude of maximum fluorodeoxyglucose uptake in primary tumors and the serum TK1 level in patients with metastatic NSCLC were found to be independent prognostic predictors of overall survival.
catalyzes the transfer of the terminal phosphate of ATP to thymidine to form thymidine 5'-phosphate (dTMP)
, thymidine kinase, cytosolic
, thymidine kinase 1, soluble
, thymidine kinase 1
, Thymidine kinase, cytosolic
, thymidine kinase
, thymidine kinase 1 soluble isoform
, thymidine kinase-1