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Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. Additionally we are shipping Thymidylate Synthetase Antibodies (178) and Thymidylate Synthetase Proteins (18) and many more products for this protein.
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Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed
SHMT1 (show SHMT1 ELISA Kits) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA
Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor GABP and Sp1 (show SP1 ELISA Kits).
downregulation of expression results in block of cell cycle expression when influenced by Fe65 (show APBB1 ELISA Kits)
posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd
Study suggests a novel function of HSP90 (show HSP90 ELISA Kits)-Src (show SRC ELISA Kits) pathway in regulation of TYMS expression and acquisition of 5-FU resistance in colon cancer.
The expression of thymidylate synthase and its correlation with survival in stage II/III gastric cancer patients
TYMS overexpression was detected in 61 % of non-small cell lung cancer patients and low expression in 39 %.
The study suggests that patients carrying rs183205964, a G>C substitution in the promoter enhancer region of TYMS, are at strongly increased risk of severe, potentially life-threatening, toxicity when treated with fluoropyrimidines.
SAHA and 5-FU act synergistically to inhibit cell growth and tumorigenicity in Hepatocellular carcinoma via the induction of cell-cycle arrest and apoptosis through a mechanism involving the inhibition of thymidylate synthase
Colorectal cancer patients with low expression of ERCC1 (show ERCC1 ELISA Kits) and thymidylate synthase have better response to therapy and show longer survival.
our data suggest that SNPs rs2847153 in TYMS gene may be a potential biomarker for predicting clinical outcome and personalized treatment in NSCLC patients.
Genetic association study of MTHFR (show MTHFR ELISA Kits) C677T polymorphism and TYMS tandem repeats in oral squamous cell carcinoma (OSCC) risk showed only TYMS tandem repeat may be associated with OSCC development.
Dihydrofolate Reductase (show DHFR ELISA Kits) and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.
These results suggest that three genetic polymorphisms in the miRNA binding sites of TYMS may be associated with cancer risk and survival of gastric cancer patients.
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
, thymidylate synthase
, thymidylate synthetase
, thymidylate synthase-like