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Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. Additionally we are shipping Thymidylate Synthetase Antibodies (275) and Thymidylate Synthetase Kits (15) and many more products for this protein.
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Human TYMS Protein expressed in Escherichia coli (E. coli) - ABIN666924
Chiu, Lai, Hsia, Yang, Lai, Wu, Ma, Yeh, Ho, Lu, Wood, Chung: Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells. in Anticancer research 2009
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Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed
SHMT1 (show SHMT1 Proteins) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA
Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (show ELF2 Proteins) GABP and Sp1 (show SP1 Proteins).
downregulation of expression results in block of cell cycle expression when influenced by Fe65 (show APBB1 Proteins)
posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd
Thymidylate Synthase Polymorphisms are associated with the Risk of Lung Cancer.
Study suggests a novel function of HSP90 (show HSP90 Proteins)-Src (show SRC Proteins) pathway in regulation of TYMS expression and acquisition of 5-FU resistance in colon cancer.
The expression of thymidylate synthase and its correlation with survival in stage II/III gastric cancer patients
TYMS overexpression was detected in 61 % of non-small cell lung cancer patients and low expression in 39 %.
The study suggests that patients carrying rs183205964, a G>C substitution in the promoter enhancer region of TYMS, are at strongly increased risk of severe, potentially life-threatening, toxicity when treated with fluoropyrimidines.
SAHA and 5-FU act synergistically to inhibit cell growth and tumorigenicity in Hepatocellular carcinoma via the induction of cell-cycle arrest and apoptosis through a mechanism involving the inhibition of thymidylate synthase
Colorectal cancer patients with low expression of ERCC1 (show ERCC1 Proteins) and thymidylate synthase have better response to therapy and show longer survival.
our data suggest that SNPs rs2847153 in TYMS gene may be a potential biomarker for predicting clinical outcome and personalized treatment in NSCLC patients.
Genetic association study of MTHFR (show MTHFR Proteins) C677T polymorphism and TYMS tandem repeats in oral squamous cell carcinoma (OSCC) risk showed only TYMS tandem repeat may be associated with OSCC development.
Dihydrofolate Reductase (show DHFR Proteins) and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
, thymidylate synthase
, thymidylate synthetase
, thymidylate synthase-like