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Thymidylate Synthetase Proteins (TYMS)

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. Additionally we are shipping Thymidylate Synthetase Antibodies (275) and Thymidylate Synthetase Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse TYMS TYMS 22171 P07607
TYMS 7298 P04818
TYMS 29261 P45352
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Top Thymidylate Synthetase Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
Yeast Herpesvirus ateles His tag   1 mg Log in to see 56 to 66 Days
$2,764.67
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Agrobacterium vitis His tag   1 mg Log in to see 56 to 66 Days
$2,684.00
Details
Yeast Azotobacter His tag   1 mg Log in to see 56 to 66 Days
$2,684.00
Details
Yeast Bifidobacterium longum His tag   1 mg Log in to see 56 to 66 Days
$2,691.33
Details
Yeast Streptococcus sanguinis His tag   1 mg Log in to see 56 to 66 Days
$2,731.67
Details
Yeast REACT_Pig roundworm His tag   1 mg Log in to see 56 to 66 Days
$2,777.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
Details

TYMS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Rat (Rattus)

Top referenced Thymidylate Synthetase Proteins

  1. Human TYMS Protein expressed in Escherichia coli (E. coli) - ABIN666924 : Chiu, Lai, Hsia, Yang, Lai, Wu, Ma, Yeh, Ho, Lu, Wood, Chung: Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells. in Anticancer research 2009 (PubMed)
    Show all 2 references for ABIN666924

More Proteins for Thymidylate Synthetase (TYMS) Interaction Partners

Mouse (Murine) Thymidylate Synthetase (TYMS) interaction partners

  1. Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed

  2. SHMT1 (show SHMT1 Proteins) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA

  3. Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (show ELF2 Proteins) GABP and Sp1 (show SP1 Proteins).

  4. downregulation of expression results in block of cell cycle expression when influenced by Fe65 (show APBB1 Proteins)

  5. posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd

Human Thymidylate Synthetase (TYMS) interaction partners

  1. Thymidylate Synthase Polymorphisms are associated with the Risk of Lung Cancer.

  2. Study suggests a novel function of HSP90 (show HSP90 Proteins)-Src (show SRC Proteins) pathway in regulation of TYMS expression and acquisition of 5-FU resistance in colon cancer.

  3. The expression of thymidylate synthase and its correlation with survival in stage II/III gastric cancer patients

  4. TYMS overexpression was detected in 61 % of non-small cell lung cancer patients and low expression in 39 %.

  5. The study suggests that patients carrying rs183205964, a G>C substitution in the promoter enhancer region of TYMS, are at strongly increased risk of severe, potentially life-threatening, toxicity when treated with fluoropyrimidines.

  6. SAHA and 5-FU act synergistically to inhibit cell growth and tumorigenicity in Hepatocellular carcinoma via the induction of cell-cycle arrest and apoptosis through a mechanism involving the inhibition of thymidylate synthase

  7. Colorectal cancer patients with low expression of ERCC1 (show ERCC1 Proteins) and thymidylate synthase have better response to therapy and show longer survival.

  8. our data suggest that SNPs rs2847153 in TYMS gene may be a potential biomarker for predicting clinical outcome and personalized treatment in NSCLC patients.

  9. Genetic association study of MTHFR (show MTHFR Proteins) C677T polymorphism and TYMS tandem repeats in oral squamous cell carcinoma (OSCC) risk showed only TYMS tandem repeat may be associated with OSCC development.

  10. Dihydrofolate Reductase (show DHFR Proteins) and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.

Thymidylate Synthetase (TYMS) Protein Profile

Protein Summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Gene names and symbols associated with Thymidylate Synthetase Proteins (TYMS)

  • thymidylate synthetase (TYMS)
  • thymidylate synthetase (thyA)
  • thymidylate synthetase (td)
  • thymidylate synthetase (thyE)
  • thymidylate synthetase (LOC100037674)
  • thymidylate synthetase (tyms)
  • thymidylate synthetase (LOC100222097)
  • thymidylate synthase (Tyms)
  • thymidylate synthetase (Tyms)
  • ECK2823 protein
  • FN1 protein
  • HST422 protein
  • JW2795 protein
  • TMS protein
  • TS protein

Protein level used designations for Thymidylate Synthetase Proteins (TYMS)

fibronectin 1 , thymidylate synthase , thymidylate synthetase , thymidylate synthase-like , Tsase , TSase , TS

GENE ID SPECIES
740018 Pan troglodytes
949035 Escherichia coli str. K-12 substr. MG1655
4156567 Aeromonas phage 25
4405636 Enterobacteria phage RB32
7803492 Enterobacteria phage RB51
9415915 Ralstonia solanacearum CFBP2957
9431860 Xenorhabdus nematophila ATCC 19061
9487079 Staphylococcus aureus
9732454 Dickeya dadantii 3937
100037674 Ovis aries
100125228 Xenopus laevis
100222097 Taeniopygia guttata
100459110 Pongo abelii
697580 Macaca mulatta
7803982 Enterobacteria phage RB14
7992740 Methylobacterium extorquens AM1
8195292 Methylobacterium extorquens DM4
8833316 Xenorhabdus bovienii SS-2004
8913233 Erwinia amylovora CFBP1430
9404045 Herbaspirillum seropedicae SmR1
9408872 Ralstonia solanacearum PSI07
22171 Mus musculus
7298 Homo sapiens
29261 Rattus norvegicus
507631 Bos taurus
100627209 Sus scrofa
421060 Gallus gallus
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