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anti-Thymocyte Selection Associated (THEMIS) Antibodies

THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Additionally we are shipping THEMIS Proteins (4) and THEMIS Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
THEMIS 387357 Q8N1K5
THEMIS 210757 Q8BGW0
THEMIS    
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Top anti-THEMIS Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB THEMIS Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human thymoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of THEMIS Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. THEMIS Antibody (C-term) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the THEMIS antibody detected the THEMIS protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Rabbit Un-conjugated IHC (p), WB THEMIS Antibody (C-term) (ABIN655135) immunohistochemistry analysis in formalin fixed and paraffin embedded human thymoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Goat Un-conjugated EIA, WB Antibody (0.3µg/ml) staining of Mouse Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Mouse Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney tissue labeled with Anti-THEMIS Polyclonal Antibody, Unconjugated 1:400 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human kidney tissue labeled with Anti-THEMIS Polyclonal Antibody, Unconjugated 1:400 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 14 to 21 Days
$269.50
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 5 to 6 Days
$269.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Mouse Rat Un-conjugated FACS, WB   100 μg Log in to see 8 to 10 Days
$793.83
Details

THEMIS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-THEMIS Antibodies

  1. Human Polyclonal THEMIS Primary Antibody for EIA, WB - ABIN492733 : Lesourne, Uehara, Lee, Song, Li, Pinkhasov, Zhang, Weng, Wildt, Wang, Bosselut, Love: Themis, a T cell-specific protein important for late thymocyte development. in Nature immunology 2009 (PubMed)
    Show all 6 references for ABIN492733

  2. Human Polyclonal THEMIS Primary Antibody for EIA, IHC (p) - ABIN955183 : Patrick, Oda, Hayakawa, Sato, Eshima, Kirikae, Iemura, Shirai, Abe, Natsume, Sasazuki, Suzuki: Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 5 references for ABIN955183

  3. Human Monoclonal THEMIS Primary Antibody for WB - ABIN2689927 : Fu, Vallée, Rybakin, McGuire, Ampudia, Brockmeyer, Salek, Fallen, Hoerter, Munshi, Huang, Hu, Fox, Sauer, Acuto, Gascoigne: Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. in Nature immunology 2009 (PubMed)
    Show all 4 references for ABIN2689927

More Antibodies against THEMIS Interaction Partners

Human Thymocyte Selection Associated (THEMIS) interaction partners

  1. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  2. THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls.

  3. THEMIS binding to GRB2 (show GRB2 Antibodies) was required for thymocyte development.

  4. SPOP (show SPOP Antibodies) mutations may define a new molecular subtype of prostate cancer.

  5. specific role for THEMIS in early TCR signalosome function

  6. Functional characterization of the homologous mouse gene.

  7. Functional analysis of the mouse gene by knockout, and comparison of the mouse a (show PTCRA Antibodies)nd human proteins.

Mouse (Murine) Thymocyte Selection Associated (THEMIS) interaction partners

  1. The results demonstrate an essential requirement for the PRR (show PVRL1 Antibodies) and NLS (show ALDH1A2 Antibodies) motifs but not the conserved CABIT cysteines for Themis1 function.

  2. THEMIS is required for the development and ultimately the function of proinflammatory T cells.

  3. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  4. by dampening mild T-cell receptor signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens

  5. specific role for THEMIS in early TCR signalosome function

  6. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

  7. Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation.

  8. Themis had high expression in thymocytes between the pre-T cell antigen receptor (show PTCRA Antibodies) and positive-selection checkpoints and low expression in mature T cells. Themis-deficient T-cells showed defective positive selection, resulting in fewer mature thymocytes.

  9. Gasp (show GPRASP1 Antibodies) associates with Grb2 (show GRB2 Antibodies) and is required for positive selection of thymocytes

THEMIS Antigen Profile

Protein Summary

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with THEMIS

  • thymocyte selection associated (THEMIS) antibody
  • thymocyte selection associated (Themis) antibody
  • thymocyte selection associated (themis) antibody
  • A430108D01 antibody
  • bA325O24.3 antibody
  • bA325O24.4 antibody
  • BB160712 antibody
  • C6orf190 antibody
  • C6orf207 antibody
  • C9H6ORF190 antibody
  • E430004N04Rik antibody
  • Gasp antibody
  • im:7138580 antibody
  • SPOT antibody
  • thylex antibody
  • tsepa antibody

Protein level used designations for THEMIS

thymocyte selection associated , thymocyte selection pathway associated , GRB2-associated protein , protein THEMIS , signaling phosphoprotein specific for T cells , thymocyte expressed molecule involved in selection , thymocyte-expressed molecule involved in selection , grb2-associating protein , protein thylex , thymus lymphocyte exclusively expressed , Thymocyte-expressed molecule involved in selection

GENE ID SPECIES
462992 Pan troglodytes
100030867 Monodelphis domestica
100073059 Equus caballus
100078185 Ornithorhynchus anatinus
100403177 Callithrix jacchus
100454796 Pongo abelii
100482128 Ailuropoda melanoleuca
100546083 Meleagris gallopavo
100595098 Nomascus leucogenys
387357 Homo sapiens
210757 Mus musculus
540554 Bos taurus
555433 Danio rerio
484120 Canis lupus familiaris
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