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Thymocyte Selection Associated (THEMIS) ELISA Kits

THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Additionally we are shipping THEMIS Antibodies (72) and THEMIS Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human THEMIS THEMIS 387357 Q8N1K5
Anti-Mouse THEMIS THEMIS 210757 Q8BGW0
THEMIS 540554 A5D789
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Top THEMIS ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
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96 Tests Log in to see 11 to 13 Days
$1,029.60
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More ELISA Kits for THEMIS Interaction Partners

Human Thymocyte Selection Associated (THEMIS) interaction partners

  1. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  2. THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls.

  3. THEMIS binding to GRB2 (show GRB2 ELISA Kits) was required for thymocyte development.

  4. SPOP (show SPOP ELISA Kits) mutations may define a new molecular subtype of prostate cancer.

  5. specific role for THEMIS in early TCR signalosome function

  6. Functional characterization of the homologous mouse gene.

  7. Functional analysis of the mouse gene by knockout, and comparison of the mouse a (show PTCRA ELISA Kits)nd human proteins.

Mouse (Murine) Thymocyte Selection Associated (THEMIS) interaction partners

  1. The results demonstrate an essential requirement for the PRR (show PVRL1 ELISA Kits) and NLS (show ALDH1A2 ELISA Kits) motifs but not the conserved CABIT cysteines for Themis1 function.

  2. THEMIS is required for the development and ultimately the function of proinflammatory T cells.

  3. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  4. by dampening mild T-cell receptor signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens

  5. specific role for THEMIS in early TCR signalosome function

  6. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

  7. Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation.

  8. Themis had high expression in thymocytes between the pre-T cell antigen receptor (show PTCRA ELISA Kits) and positive-selection checkpoints and low expression in mature T cells. Themis-deficient T-cells showed defective positive selection, resulting in fewer mature thymocytes.

  9. Gasp (show GPRASP1 ELISA Kits) associates with Grb2 (show GRB2 ELISA Kits) and is required for positive selection of thymocytes

THEMIS Antigen Profile

Antigen Summary

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with THEMIS

  • thymocyte selection associated (THEMIS) antibody
  • thymocyte selection associated (Themis) antibody
  • thymocyte selection associated (themis) antibody
  • A430108D01 antibody
  • bA325O24.3 antibody
  • bA325O24.4 antibody
  • BB160712 antibody
  • C6orf190 antibody
  • C6orf207 antibody
  • C9H6ORF190 antibody
  • E430004N04Rik antibody
  • Gasp antibody
  • im:7138580 antibody
  • SPOT antibody
  • thylex antibody
  • tsepa antibody

Protein level used designations for THEMIS

thymocyte selection associated , thymocyte selection pathway associated , GRB2-associated protein , protein THEMIS , signaling phosphoprotein specific for T cells , thymocyte expressed molecule involved in selection , thymocyte-expressed molecule involved in selection , grb2-associating protein , protein thylex , thymus lymphocyte exclusively expressed , Thymocyte-expressed molecule involved in selection

GENE ID SPECIES
462992 Pan troglodytes
100030867 Monodelphis domestica
100073059 Equus caballus
100078185 Ornithorhynchus anatinus
100403177 Callithrix jacchus
100454796 Pongo abelii
100482128 Ailuropoda melanoleuca
100546083 Meleagris gallopavo
100595098 Nomascus leucogenys
387357 Homo sapiens
210757 Mus musculus
540554 Bos taurus
555433 Danio rerio
484120 Canis lupus familiaris
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