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Thymocyte Selection Associated Proteins (THEMIS)

THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Additionally we are shipping THEMIS Antibodies (72) and THEMIS Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
THEMIS 387357 Q8N1K5
THEMIS 210757 Q8BGW0
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Top THEMIS Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 11 to 12 Days
$362.88
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

THEMIS Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Thymocyte Selection Associated (THEMIS) Interaction Partners

Human Thymocyte Selection Associated (THEMIS) interaction partners

  1. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  2. THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls.

  3. THEMIS binding to GRB2 (show GRB2 Proteins) was required for thymocyte development.

  4. SPOP (show SPOP Proteins) mutations may define a new molecular subtype of prostate cancer.

  5. specific role for THEMIS in early TCR signalosome function

  6. Functional characterization of the homologous mouse gene.

  7. Functional analysis of the mouse gene by knockout, and comparison of the mouse a (show PTCRA Proteins)nd human proteins.

Mouse (Murine) Thymocyte Selection Associated (THEMIS) interaction partners

  1. The results demonstrate an essential requirement for the PRR (show PVRL1 Proteins) and NLS (show ALDH1A2 Proteins) motifs but not the conserved CABIT cysteines for Themis1 function.

  2. THEMIS is required for the development and ultimately the function of proinflammatory T cells.

  3. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  4. by dampening mild T-cell receptor signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens

  5. specific role for THEMIS in early TCR signalosome function

  6. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

  7. Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation.

  8. Themis had high expression in thymocytes between the pre-T cell antigen receptor (show PTCRA Proteins) and positive-selection checkpoints and low expression in mature T cells. Themis-deficient T-cells showed defective positive selection, resulting in fewer mature thymocytes.

  9. Gasp (show GPRASP1 Proteins) associates with Grb2 (show GRB2 Proteins) and is required for positive selection of thymocytes

THEMIS Protein Profile

Protein Summary

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with THEMIS

  • thymocyte selection associated (THEMIS)
  • thymocyte selection associated (Themis)
  • thymocyte selection associated (themis)
  • A430108D01 protein
  • bA325O24.3 protein
  • bA325O24.4 protein
  • BB160712 protein
  • C6orf190 protein
  • C6orf207 protein
  • C9H6ORF190 protein
  • E430004N04Rik protein
  • Gasp protein
  • im:7138580 protein
  • SPOT protein
  • thylex protein
  • tsepa protein

Protein level used designations for THEMIS

thymocyte selection associated , thymocyte selection pathway associated , GRB2-associated protein , protein THEMIS , signaling phosphoprotein specific for T cells , thymocyte expressed molecule involved in selection , thymocyte-expressed molecule involved in selection , grb2-associating protein , protein thylex , thymus lymphocyte exclusively expressed , Thymocyte-expressed molecule involved in selection

GENE ID SPECIES
462992 Pan troglodytes
100030867 Monodelphis domestica
100073059 Equus caballus
100078185 Ornithorhynchus anatinus
100403177 Callithrix jacchus
100454796 Pongo abelii
100482128 Ailuropoda melanoleuca
100546083 Meleagris gallopavo
100595098 Nomascus leucogenys
387357 Homo sapiens
210757 Mus musculus
540554 Bos taurus
555433 Danio rerio
484120 Canis lupus familiaris
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