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THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Additionally we are shipping THEMIS Antibodies (91) and THEMIS Proteins (4) and many more products for this protein.
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we have demonstrated mutually exclusive use of exon 1 and 2 amongst 16 novel THEMIS isoforms. We also show inverse correlation between THEMIS expression in human CD4 (show CD4 ELISA Kits)+ T-cells and dosage of the multiple sclerosis risk allele at rs13204742, driven by reduced expression of exon 1- containing isoforms
we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.
the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.
THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls.
THEMIS binding to GRB2 (show GRB2 ELISA Kits) was required for thymocyte development.
SPOP (show SPOP ELISA Kits) mutations may define a new molecular subtype of prostate cancer.
specific role for THEMIS in early TCR signalosome function
Functional characterization of the homologous mouse gene.
Functional analysis of the mouse gene by knockout, and comparison of the mouse a (show PTCRA ELISA Kits)nd human proteins.
the positive selection of immature CD4 (show CD4 ELISA Kits)+CD8 (show CD8A ELISA Kits)+ double-positive thymocytes and their commitment to the CD4 (show CD4 ELISA Kits)+CD8 (show CD8A ELISA Kits)- single-positive stage are impaired in Themis-/- mice
The results demonstrate an essential requirement for the PRR (show PVRL1 ELISA Kits) and NLS (show ALDH1A2 ELISA Kits) motifs but not the conserved CABIT cysteines for Themis1 function.
THEMIS is required for the development and ultimately the function of proinflammatory T cells.
by dampening mild T-cell receptor signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection
Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation.
Themis had high expression in thymocytes between the pre-T cell antigen receptor (show PTCRA ELISA Kits) and positive-selection checkpoints and low expression in mature T cells. Themis-deficient T-cells showed defective positive selection, resulting in fewer mature thymocytes.
This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.
thymocyte selection associated
, thymocyte selection pathway associated
, GRB2-associated protein
, protein THEMIS
, signaling phosphoprotein specific for T cells
, thymocyte expressed molecule involved in selection
, thymocyte-expressed molecule involved in selection
, grb2-associating protein
, protein thylex
, thymus lymphocyte exclusively expressed
, Thymocyte-expressed molecule involved in selection