Thymopoietin Proteins (TMPO)

The protein encoded by TMPO resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. Additionally we are shipping Thymopoietin Antibodies (112) and Thymopoietin Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TMPO TMPO 25359 Q62733
TMPO 7112 P42166 , P42167
TMPO 21917 Q61033 , Q61029
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Top Thymopoietin Proteins at

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
HOST_Escherichia coli (E. coli) Human His tag Human TMPO, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 5 Days
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days

TMPO Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

More Proteins for Thymopoietin (TMPO) Interaction Partners

Human Thymopoietin (TMPO) interaction partners

  1. Study found TMPO is significantly upregulated in glioblastoma tissues.TMPO knockdown promoted cell apoptosis by upregulation of the cleavage of caspase-3 (show CASP3 Proteins) and PARP protein levels.

  2. The findings unveil a unique mechanism where the nuclear periphery proteins lamin-A/C (show LMNA Proteins), LAP2alpha and BAF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle.

  3. The authors find that LAP2alpha (lamina-associated polypeptide-alpha) interacts with lamin A (show LMNA Proteins), while its interaction with progerin is significantly reduced.

  4. Results highlight the interactions at the nuclear envelope where mutations in the EMD (show EMD Proteins) and TMPO gene in combination with mutations in SUN1 (show SUN1 Proteins) have an impact on several components of the network.

  5. Data indicate that cells lacking either high mobility group (show SSRP1 Proteins) protein N5 (HMGN5 (show HMGN5 Proteins)) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner.

  6. this study provides evidence for elevated LAP2alpha expression in cervical cancer and suggests that E2F (show E2F1 Proteins) and p53 (show TP53 Proteins) activities associate with the positive and negative regulation of LAP2alpha expression, respectively

  7. data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha-lamin A/C (show LMNA Proteins) complexes

  8. Results indicate that in vitro, the interaction between HA95 (show AKAP8L Proteins) and LAP2beta is influenced by a PKA-mediated phosphorylation of HA95 (show AKAP8L Proteins) rather than by CDK1 (show CDK1 Proteins)- or PKC (show PRRT2 Proteins)-mediated phosphorylation of LAP2beta

  9. LAP2alpha and BAF (show BANF1 Proteins) transiently localize to telomeres and specific regions on chromatin during nuclear assembly

  10. A predicted Arg690Cys substitution within the LAP2 (show ERBB2IP Proteins) gene is implicated in the pathogenesis of genetic forms of dilated cardiomyopathy.

Cow (Bovine) Thymopoietin (TMPO) interaction partners

  1. Lamin (show LMNA Proteins)-associated polypeptide (LAP)2 beta assembles around only alternative oocyte chromatin after complete dephosphorylation of histone H3 (show HIST3H3 Proteins) following fertilization and activation. (lamina-associated polypeptide 2; LAP2beta)

Mouse (Murine) Thymopoietin (TMPO) interaction partners

  1. Lifespan and body mass were increased in Lmna (show LMNA Proteins)(-/-)Lap2alpha(-/-) mice compared with Lmna (show LMNA Proteins) deficient mice.

  2. Data indicate that a LAP2alpha-independent assembly defect of DeltaK32 lamin A/C (show LMNA Proteins) is the cause of the pathology, whereas the LAP2alpha-linked functions of nucleoplasmic lamin A/C (show LMNA Proteins) in the regulation of tissue progenitor cells are not affected in Lmna (show LMNA Proteins)(DeltaK32/DeltaK32) mice.

  3. LAP2alpha serves as a transcriptional co-regulator, which controls muscle specific (show EIF3K Proteins) gene expression during muscle regeneration, muscle remodeling and stress response.

  4. TSLP (show TSLP Proteins) diverts airway tolerance against ovalbumin (show OVA Proteins) (OVA) to T helper cell type (Th)2 sensitization and inhibits the generation of OVA-specific inducible regulatory T cells.

  5. The age-related down-regulation of Wnt4 (show WNT4 Proteins) (and subsequently FoxN1 (show FOXN2 Proteins)), and the prominent increase in LAP2alpha expression, was investigated in thymic epithelial cells.

  6. Our data demonstrate multiple and distinct functions of LAP2 alpha in muscle stem cell maintenance, early phases of myogenic differentiation, and muscle remodeling.

  7. Data show that LAP2alpha knockout caused systolic dysfunction in young mice, sporadic fibrosis in old animals, and disregulation of cardiac GATA4 (show GATA4 Proteins) and MEF2c (show MEF2C Proteins), while dstrophin deficiency in Mdx (show DMD Proteins) mice resulted in a transient rescue of Lap2alpha(-/-) phenotype.

  8. In agreement with its regulation by E2F (show E2F1 Proteins), LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate

  9. Loss of LAP2-Lmna (show LMNA Proteins) complexes causes erythroid and epidermal progenitor hyperproliferation.

Thymopoietin (TMPO) Protein Profile

Protein Summary

The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with Thymopoietin Proteins (TMPO)

  • thymopoietin (TMPO)
  • thymopoietin (Tmpo)
  • thymopoietin (tmpo)
  • thymopoietin a (tmpoa)
  • 5630400D24Rik protein
  • AI195756 protein
  • AI606875 protein
  • AW214352 protein
  • AW547477 protein
  • CMD1T protein
  • lap2 protein
  • LAP2beta protein
  • LEMD4 protein
  • PRO0868 protein
  • tmpo protein
  • TP protein
  • wu:fc26f12 protein
  • wu:fd21f02 protein
  • wu:fi29h05 protein

Protein level used designations for Thymopoietin Proteins (TMPO)

thymopoietin , lamina-associated polypeptide 2, isoform alpha-like , TP beta , Thymopoietin (lamina associated polypeptide 2) , lamina-associated polypeptide 2 , thymopoietin isoform beta , LEM domain containing 4 , TP alpha , TP beta/gamma , thymopoietin-related peptide isoform alpha , thymopoietin-related peptide isoforms beta/gamma , lamina associated polypeptide 2 , lamin-associated polypeptide 2beta , thymopoietin II , thymopoietin-2 , etID53005.4 , lamina-associated protein 2

452151 Pan troglodytes
693387 Macaca mulatta
100387152 Callithrix jacchus
100457982 Pongo abelii
100588465 Nomascus leucogenys
25359 Rattus norvegicus
7112 Homo sapiens
397975 Xenopus laevis
417923 Gallus gallus
482618 Canis lupus familiaris
510267 Bos taurus
21917 Mus musculus
352907 Danio rerio
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