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The protein encoded by TOX contains a HMG box DNA binding domain. Additionally we are shipping TOX Antibodies (9) and TOX Kits (2) and many more products for this protein.
The expression of Sezary signature genes: FCRL3 (show FCRL3 Proteins), Tox, and miR (show MLXIP Proteins)-214, was significantly higher in samples from Sezary syndrome patients with CD164 (show CD164 Proteins) expressing CD4 (show CD4 Proteins)(+) T cells.
Significant associations between single nucleotide polymorphisms in TOX, CDKN2A/B and type 2 diabetes meillitus.
The SLC2A9 (rs7660895) and TOX (rs11777927) gene polymorphisms may be associated with formation of intracranial aneurysms, and rs7660895 may be associated with intracranial aneurysms rupture.
TOX may be a specific marker for tumour cells in some types of cutaneous lymphoma.
High TOX transcript levels correlate with increased cutaneous T-cell lymphoma.
SNP rs2726600 is located in a transcription-factor binding site in the 3' region of TOX.
Compared with TOX4, expression of TOX1, TOX2 (show TOX2 Proteins) and TOX3 (show TOX3 Proteins) in normal lung was 25, 44, and 88%lower, respectively, supporting the premise that reduced promoter activity confers increased susceptibility to methylation during lung carcinogenesis.
results suggest that TOX is required for IL-15-mediated natural killer (NK) cell differentiation and affected expression of T-bet that plays critical roles in NK differentiation and maturation
expression of the HMG (show SSRP1 Proteins) box protein TOX is sufficient to induce changes in coreceptor gene expression associated with beta-selection, including CD8 (show CD8A Proteins) gene demethylation
TOX is necessary to establish the CD4 (show CD4 Proteins)(+) T cell lineage gene program.
TOX has been identified as an essential regulator of the development of multiple facets of the adaptive immune system and have added another commonality to the developmental pathways of Natural killer cells and lymphoid tissue inducer cells.
The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.
thymocyte selection-associated high mobility group box protein TOX
, thymus high mobility group box protein TOX
, thymocyte selection-associated HMG box