Thymus High Mobility Group Box Protein Proteins (TOX)

The protein encoded by TOX contains a HMG box DNA binding domain. Additionally we are shipping TOX Antibodies (10) and TOX Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Human TOX TOX 9760 O94900
Mouse TOX TOX 252838 Q66JW3
Rat TOX TOX 362481  
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More Proteins for Thymus High Mobility Group Box Protein (TOX) Interaction Partners

Human Thymus High Mobility Group Box Protein (TOX) interaction partners

  1. TOX expression is insufficient for diagnosis of cutaneous T-cell lymphoma

  2. data suggest that GATA3 (show GATA3 Proteins) regulates TOX, revealing insight into TOX regulation

  3. The expression of Sezary signature genes: FCRL3 (show FCRL3 Proteins), Tox, and miR (show MLXIP Proteins)-214, was significantly higher in samples from Sezary syndrome patients with CD164 (show CD164 Proteins) expressing CD4 (show CD4 Proteins)(+) T cells.

  4. Significant associations between single nucleotide polymorphisms in TOX, CDKN2A/B and type 2 diabetes meillitus.

  5. The SLC2A9 (rs7660895) and TOX (rs11777927) gene polymorphisms may be associated with formation of intracranial aneurysms, and rs7660895 may be associated with intracranial aneurysms rupture.

  6. TOX may be a specific marker for tumour cells in some types of cutaneous lymphoma.

  7. High TOX transcript levels correlate with increased cutaneous T-cell lymphoma.

  8. SNP rs2726600 is located in a transcription-factor binding site in the 3' region of TOX.

  9. Compared with TOX4, expression of TOX1, TOX2 (show TOX2 Proteins) and TOX3 (show TOX3 Proteins) in normal lung was 25, 44, and 88%lower, respectively, supporting the premise that reduced promoter activity confers increased susceptibility to methylation during lung carcinogenesis.

  10. results suggest that TOX is required for IL-15-mediated natural killer (NK) cell differentiation and affected expression of T-bet that plays critical roles in NK differentiation and maturation

Mouse (Murine) Thymus High Mobility Group Box Protein (TOX) interaction partners

  1. TOX is necessary to establish the CD4 (show CD4 Proteins)(+) T cell lineage gene program.

  2. TOX has been identified as an essential regulator of the development of multiple facets of the adaptive immune system and have added another commonality to the developmental pathways of Natural killer cells and lymphoid tissue inducer cells.

TOX Protein Profile

Protein Summary

The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.

Gene names and symbols associated with TOX

  • thymocyte selection associated high mobility group box (TOX)
  • thymocyte selection-associated high mobility group box (Tox)
  • 1700007F02Rik protein
  • TOX1 protein

Protein level used designations for TOX

thymocyte selection-associated high mobility group box protein TOX , thymus high mobility group box protein TOX , thymocyte selection-associated HMG box

421138 Gallus gallus
9760 Homo sapiens
486964 Canis lupus familiaris
525888 Bos taurus
252838 Mus musculus
362481 Rattus norvegicus
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