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TRIP13 encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. Additionally we are shipping TRIP13 Antibodies (76) and TRIP13 Proteins (8) and many more products for this protein.
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6 individuals with biallelic loss-of-function mutations in TRIP13 developed Wilms tumors. TRIP13-mutant patient cells have no detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC (show ADCY10 ELISA Kits)), leading to a high rate of chromosome missegregation. Individuals with biallelic TRIP13 mutations have a high risk of embryonal tumors. These experiments show that their cells display severe SAC (show ADCY10 ELISA Kits) impairment.
Thes authors show that p31 (show ATP6V1E1 ELISA Kits)(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 (show MAD2L1 ELISA Kits) N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 (show MAD2L1 ELISA Kits) in the presence of ATP.
These results establish a paradigm of the roles of p31 (show ATP6V1E1 ELISA Kits)(comet) and TRIP13 in both checkpoint activation and inactivation.
the oligomeric form of TRIP13 binds both p31(comet) and MCC
TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer.
suggest that premature mitotic checkpoint (show BUB3 ELISA Kits) silencing triggered by TRIP13 overexpression may promote cancer development
propose that TRIP13 plays centrally important roles in the sequence of events leading to MCC disassembly and checkpoint inactivation
TRIP13-deficient spermatocytes also progress to an H1t (show HIST1H1T ELISA Kits)-positive stage if ATM (show ATM ELISA Kits) activity is attenuated by hypomorphic mutations in Mre11 (show MRE11A ELISA Kits) or Nbs1 (show NBN ELISA Kits) or by elimination of the ATM (show ATM ELISA Kits)-effector kinase CHK2 (show CHEK2 ELISA Kits)
TRIP13 is required for recombination and normal higher-order chromosome structure during meiosis.
HORMAD1 (show HORMAD1 ELISA Kits) and HORMAD2 (show HORMAD2 ELISA Kits) are depleted from synapsed chromosome axes with the help of TRIP13.
results demonstrate that in mice, the primary meiotic function of TRIP13 is in recombination itself
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer.
TR-interacting protein 13 homolog
, TRIP-13 homolog
, pachytene checkpoint protein 2 homolog
, thyroid hormone receptor interactor 13 homolog
, thyroid receptor-interacting protein 13 homolog
, Thyroid hormone receptor interactor 13 homolog
, Thyroid receptor-interacting protein 13 homolog
, thyroid hormone receptor interactor 13
, thyroid receptor-interacting protein 13-like
, HPV16 E1 protein binding protein
, HPV16 E1 protein-binding protein
, TR-interacting protein 13
, human papillomavirus type 16 E1 protein-binding protein
, thyroid receptor interacting protein 13
, thyroid receptor-interacting protein 13
, Pachytene checkpoint protein 2 homolog
, Thyroid receptor-interacting protein 13