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The protein encoded by THRSP is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. Additionally we are shipping Thyroid Hormone Responsive Kits (13) and Thyroid Hormone Responsive Proteins (6) and many more products for this protein.
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S14 has a potential role in regulating mammary tumor growth and fatty acid synthesis in vivo. Modulating the amount of medium chain fatty acids, by changing the levels of S14, has the potential to impact malignant mammary tumor phenotypes.
Data indicate SPOT14 as a potent marker for adult NSPCs that react dynamically to positive and negative neurogenic regulators.
Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor alpha (show NR1H3 Antibodies) through a sterol regulatory element-binding protein (show CNBP Antibodies) 1c-dependent mechanism in mice.
The structure of S14 suggests a mechanism whereby heterodimer formation with MIG12 attenuates the ability of MIG12 to activate ACC.
Spot 14 protein, absent in the lactating mammary gland, is required for maximum efficiency of de novo lipid synthesis in vivo
the daily rhythm of Spot14 expression in the liver is under the control of the light-entrainable oscillator, food-entrainable oscillator, and food-derived nutrients, in a separate or cooperative manner
the S14-R protein is a compensatory factor, at least partially responsible for the normal liver lipogenesis observed in the S14 null mouse
In human breast cancer cell lines, S14 (show PSMD8 Antibodies) expression was highest in those representing the luminal subtype compared to those cell lines with basal characteristics.
N-terminally truncated human Thrsp and its selenomethionyl derivative were collected to 4.0, 3.0 and 3.6 A resolution
significantly greater thyroid hormone (show PTH Antibodies) response for the human promoter, compared with the rat.
human Spot 14 protein might regulate the p53 (show TP53 Antibodies) target gene, p21(WAF1/Cip1 (show CDKN1A Antibodies)), via its direct interaction with the thyroid receptor or other p53 (show TP53 Antibodies) coactivators, such as Zac1 (show PLAGL1 Antibodies).
Weaning-to-oestrus interval (WEI) was associated with five single nucleotide polymorphisms (SNPs). A single THRSP SNP maintained an association with WEI after correction testing.
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.
, spot 14 protein
, thyroid hormone responsive SPOT14 homolog
, thyroid hormone-inducible hepatic protein
, Lipogenic protein S14
, SPOT14 homolog
, lipogenic protein 1
, thyroid hormone responsive (SPOT14 homolog, rat)
, thyroid hormone responsive SPOT14
, thyroid hormone responsive spot 14 alpha